Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 14948-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14948-1-AP, RRID:AB_2136690
- Product name
- LMOD3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LMOD3 antibody (Cat. #14948-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lmod2 is necessary for effective skeletal muscle contraction.
Generating high-fidelity cochlear organoids from human pluripotent stem cells.
Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation.
Neonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant.
Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle.
Kleine-Levin syndrome is associated with LMOD3 variants.
HSPB7 is indispensable for heart development by modulating actin filament assembly.
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.
Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.
Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.
Gene Expression by Mouse Inner Ear Hair Cells during Development.
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Preparation of developing Xenopus muscle for sarcomeric protein localization by high-resolution imaging.
Larrinaga TM, Farman GP, Mayfield RM, Yuen M, Ahrens-Nicklas RC, Cooper ST, Pappas CT, Gregorio CC
Science advances 2024 Mar 15;10(11):eadk1890
Science advances 2024 Mar 15;10(11):eadk1890
Generating high-fidelity cochlear organoids from human pluripotent stem cells.
Moore ST, Nakamura T, Nie J, Solivais AJ, Aristizábal-Ramírez I, Ueda Y, Manikandan M, Reddy VS, Romano DR, Hoffman JR, Perrin BJ, Nelson RF, Frolenkov GI, Chuva de Sousa Lopes SM, Hashino E
Cell stem cell 2023 Jul 6;30(7):950-961.e7
Cell stem cell 2023 Jul 6;30(7):950-961.e7
Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation.
Berger J, Berger S, Mok YSG, Li M, Tarakci H, Currie PD
PLoS genetics 2022 Feb;18(2):e1010066
PLoS genetics 2022 Feb;18(2):e1010066
Neonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant.
Yuen M, Worgan L, Iwanski J, Pappas CT, Joshi H, Churko JM, Arbuckle S, Kirk EP, Zhu Y, Roscioli T, Gregorio CC, Cooper ST
European journal of human genetics : EJHG 2022 Apr;30(4):450-457
European journal of human genetics : EJHG 2022 Apr;30(4):450-457
Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle.
Kiss B, Gohlke J, Tonino P, Hourani Z, Kolb J, Strom J, Alekhina O, Smith JE 3rd, Ottenheijm C, Gregorio C, Granzier H
Science advances 2020 Nov;6(46)
Science advances 2020 Nov;6(46)
Kleine-Levin syndrome is associated with LMOD3 variants.
Al Shareef SM, Basit S, Li S, Pfister C, Pradervand S, Lecendreux M, Mayer G, Dauvilliers Y, Salpietro V, Houlden H, BaHammam AS, Tafti M
Journal of sleep research 2019 Jun;28(3):e12718
Journal of sleep research 2019 Jun;28(3):e12718
HSPB7 is indispensable for heart development by modulating actin filament assembly.
Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J
Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):11956-11961
Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):11956-11961
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
Ramirez-Martinez A, Cenik BK, Bezprozvannaya S, Chen B, Bassel-Duby R, Liu N, Olson EN
eLife 2017 Aug 9;6
eLife 2017 Aug 9;6
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.
Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC
Proceedings of the National Academy of Sciences of the United States of America 2015 Nov 3;112(44):13573-8
Proceedings of the National Academy of Sciences of the United States of America 2015 Nov 3;112(44):13573-8
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF
The Journal of clinical investigation 2015 Jan;125(1):456-7
The Journal of clinical investigation 2015 Jan;125(1):456-7
Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.
Nworu CU, Kraft R, Schnurr DC, Gregorio CC, Krieg PA
Journal of cell science 2015 Jan 15;128(2):239-50
Journal of cell science 2015 Jan 15;128(2):239-50
Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.
Gokhin DS, Ochala J, Domenighetti AA, Fowler VM
Development (Cambridge, England) 2015 Dec 15;142(24):4351-62
Development (Cambridge, England) 2015 Dec 15;142(24):4351-62
Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.
Cenik BK, Garg A, McAnally JR, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN, Liu N
The Journal of clinical investigation 2015 Apr;125(4):1569-78
The Journal of clinical investigation 2015 Apr;125(4):1569-78
Gene Expression by Mouse Inner Ear Hair Cells during Development.
Scheffer DI, Shen J, Corey DP, Chen ZY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 22;35(16):6366-80
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 22;35(16):6366-80
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF
The Journal of clinical investigation 2014 Nov;124(11):4693-708
The Journal of clinical investigation 2014 Nov;124(11):4693-708
KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Garg A, O'Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, Nelson BR, Beetz N, Li L, Chen S, Laing NG, Grange RW, Bassel-Duby R, Olson EN
The Journal of clinical investigation 2014 Aug;124(8):3529-39
The Journal of clinical investigation 2014 Aug;124(8):3529-39
Preparation of developing Xenopus muscle for sarcomeric protein localization by high-resolution imaging.
Nworu CU, Krieg PA, Gregorio CC
Methods (San Diego, Calif.) 2014 Apr 1;66(3):370-9
Methods (San Diego, Calif.) 2014 Apr 1;66(3):370-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 14948-1-AP(LMOD3 antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LMOD3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LMOD3. This antibody recognizes human, mouse antigen. The LMOD3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.