BS60691

antibody from Bioworld Technology, Inc
Targeting: PODXL2 endoglycan, PODLX2
Provider product page for BS60691

Antibody data

Product number
BS60691 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PODXL2 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human PODXL2
Description
Endoglycan, also known as podocalyxin-like 2, exists as a disulfide-dependent homodimer and belongs to the CD34 family of proteins. It is a proteoglycan modified with chondroitin sulfate chains and (with appropriate post-translational modifications) functions as an L-selectin ligand, interacting via sulfation on two tyrosine residues. Endoglycan contains a membrane proximal globular domain, a single pass transmembrane domain, a mucin-like domain and a highly acidic N-terminal with O-linked sLex structures. It is widely expressed with distribution including endothelial cells, hematopoietic precursors and leukocyte subpopulations. Endoglycan is similar to PSGL-1 in that it also exhibits catch-slip transitional bonds. These bonds help to mediate the rolling and tethering of circulating leukocytes on vascular surfaces, typically during immune surveillance and inflammation. The ligand activity of Endoglycan is dependent on sialylation and fucosylation and may mediate adhesion events.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PODXL2 protein structure - BS60691 shown in red.