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Targeting: THOC1
HPR1, P84
Western blot Immunocytochemistry Immunoprecipitation
Immunohistochemistry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [106]
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- Western blot [8]
- Immunocytochemistry [2]
- Immunoprecipitation [1]
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- GTX70220 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX70220, RRID:AB_372637
- Product name
- Nuclear Matrix Protein p84 antibody [5E10]
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Rat, Hamster, Simian
- Host
- Mouse
Submitted references High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency.
RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.
Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.
Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas.
Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus.
SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts.
Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing.
ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response.
Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.
Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice.
Identification of neuron selective androgen receptor inhibitors.
Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.
Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway.
Platelet activating factor-induced expression of p21 is correlated with histone acetylation.
Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses.
Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1.
A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity.
Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging.
Using a Fluorescent PCR-capillary Gel Electrophoresis Technique to Genotype CRISPR/Cas9-mediated Knockout Mutants in a High-throughput Format.
Gut microbiota directs PPARγ-driven reprogramming of the liver circadian clock by nutritional challenge.
Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury.
Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species.
NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration.
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells.
Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β.
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.
IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation.
ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma.
The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.
Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.
Endothelial cell tumor growth is Ape/ref-1 dependent.
Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.
Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.
Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells.
Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome.
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells.
USP7 cooperates with SCML2 to regulate the activity of PRC1.
The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.
RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.
The Thoc1 ribonucleoprotein and prostate cancer progression.
Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
RNA binding protein HuR regulates the expression of ABCA1.
ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling.
Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment.
A-T : Pathogenesis of rare missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity
Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice.
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.
TRAF2 facilitates vaccinia virus replication by promoting rapid virus entry.
HIF1-α-mediated gene expression induced by vitamin B1 deficiency.
Functional Integration of the Conserved Domains of Shoc2 Scaffold.
The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance.
The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.
Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line.
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.
A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Reprogramming of the circadian clock by nutritional challenge.
DSIF restricts NF-κB signaling by coordinating elongation with mRNA processing of negative feedback genes.
Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors.
A physiological role for androgen actions in the absence of androgen receptor DNA binding activity.
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.
Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).
Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer.
Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes.
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genes.
Cancer cells and normal cells differ in their requirements for Thoc1.
Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.
Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.
The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.
Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier.
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Novel N-terminal variant of human VDR.
Characterization of the mouse JAB1 cDNA and protein.
Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH
Cell metabolism 2019 Mar 4;
Cell metabolism 2019 Mar 4;
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Huang MH, Chou YW, Li MH, Shih TE, Lin SZ, Chuang HM, Chiou TW, Su HL, Harn HJ
Pharmacological research 2019 Jan;139:50-61
Pharmacological research 2019 Jan;139:50-61
PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency.
Chen MY, Hsu WC, Hsu SC, Yang YS, Chuang TH, Lin WJ, Tan TH, Su YW
Cell death and differentiation 2018 Sep 20;
Cell death and differentiation 2018 Sep 20;
RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.
Ho SR, Lin WC
The Journal of biological chemistry 2018 Oct 19;293(42):16307-16323
The Journal of biological chemistry 2018 Oct 19;293(42):16307-16323
Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.
Bhat AA, Lu H, Soutto M, Capobianco A, Rai P, Zaika A, El-Rifai W
Oncogene 2018 Nov;37(46):6011-6024
Oncogene 2018 Nov;37(46):6011-6024
Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas.
Parekh VI, Modali SD, Welch J, Simonds WF, Weinstein LS, Kebebew E, Agarwal SK
Endocrine-related cancer 2018 May;25(5):L31-L35
Endocrine-related cancer 2018 May;25(5):L31-L35
Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus.
Wang J, Wang Y, Zhou R, Zhao J, Zhang Y, Yi D, Li Q, Zhou J, Guo F, Liang C, Li X, Cen S
Viruses 2018 Jun 16;10(6)
Viruses 2018 Jun 16;10(6)
SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts.
Li M, Xu X, Chang CW, Zheng L, Shen B, Liu Y
Nature communications 2018 Jul 13;9(1):2706
Nature communications 2018 Jul 13;9(1):2706
Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing.
Baumann J, Ignashkova TI, Chirasani SR, Ramírez-Peinado S, Alborzinia H, Gendarme M, Kuhnigk K, Kramer V, Lindemann RK, Reiling JH
Molecular biology of the cell 2018 Jan 1;29(1):42-52
Molecular biology of the cell 2018 Jan 1;29(1):42-52
ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response.
Nikolos F, Thomas C, Bado I, Gustafsson JÅ
Molecular cancer research : MCR 2018 Feb;16(2):233-242
Molecular cancer research : MCR 2018 Feb;16(2):233-242
Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
Zera K, Zastre J
PloS one 2017;12(10):e0186707
PloS one 2017;12(10):e0186707
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.
Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P
Cell metabolism 2017 Sep 5;26(3):523-538.e5
Cell metabolism 2017 Sep 5;26(3):523-538.e5
Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice.
Santiago González DA, Cheli VT, Zamora NN, Lama TN, Spreuer V, Murphy GG, Paez PM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Oct 18;37(42):10038-10051
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Oct 18;37(42):10038-10051
Identification of neuron selective androgen receptor inhibitors.
Otto-Duessel M, Tew BY, Vonderfecht S, Moore R, Jones JO
World journal of biological chemistry 2017 May 26;8(2):138-150
World journal of biological chemistry 2017 May 26;8(2):138-150
Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.
Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 24;114(4):E619-E628
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 24;114(4):E619-E628
Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway.
Wu M, Chen W, Lu Y, Zhu G, Hao L, Li YP
Nature communications 2017 Jan 19;8:13700
Nature communications 2017 Jan 19;8:13700
Platelet activating factor-induced expression of p21 is correlated with histone acetylation.
Damiani E, Puebla-Osorio N, Lege BM, Liu J, Neelapu SS, Ullrich SE
Scientific reports 2017 Feb 3;7:41959
Scientific reports 2017 Feb 3;7:41959
Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses.
Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Feb 1;37(5):1197-1212
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Feb 1;37(5):1197-1212
Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1.
Gendarme M, Baumann J, Ignashkova TI, Lindemann RK, Reiling JH
Molecular biology of the cell 2017 Dec 15;28(26):3756-3772
Molecular biology of the cell 2017 Dec 15;28(26):3756-3772
A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity.
Puschnik AS, Marceau CD, Ooi YS, Majzoub K, Rinis N, Contessa JN, Carette JE
Cell reports 2017 Dec 12;21(11):3032-3039
Cell reports 2017 Dec 12;21(11):3032-3039
Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G
Molecular cell 2017 Aug 3;67(3):484-497.e5
Molecular cell 2017 Aug 3;67(3):484-497.e5
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging.
Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA, Sassone-Corsi P
Cell 2017 Aug 10;170(4):664-677.e11
Cell 2017 Aug 10;170(4):664-677.e11
Using a Fluorescent PCR-capillary Gel Electrophoresis Technique to Genotype CRISPR/Cas9-mediated Knockout Mutants in a High-throughput Format.
Ramlee MK, Wang J, Cheung AMS, Li S
Journal of visualized experiments : JoVE 2017 Apr 8;(122)
Journal of visualized experiments : JoVE 2017 Apr 8;(122)
Gut microbiota directs PPARγ-driven reprogramming of the liver circadian clock by nutritional challenge.
Murakami M, Tognini P, Liu Y, Eckel-Mahan KL, Baldi P, Sassone-Corsi P
EMBO reports 2016 Sep;17(9):1292-303
EMBO reports 2016 Sep;17(9):1292-303
Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.
Zheng H, Dai W, Cheung AK, Ko JM, Kan R, Wong BW, Leong MM, Deng M, Kwok TC, Chan JY, Kwong DL, Lee AW, Ng WT, Ngan RK, Yau CC, Tung S, Lee VH, Lam KO, Kwan CK, Li WS, Yau S, Chan KW, Lung ML
Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 4;113(40):11283-11288
Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 4;113(40):11283-11288
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury.
Wang SM, Hsu JC, Ko CY, Chiu NE, Kan WM, Lai MD, Wang JM
Molecular neurobiology 2016 Nov;53(9):5912-5927
Molecular neurobiology 2016 Nov;53(9):5912-5927
Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species.
Aguilar-Arnal L, Ranjit S, Stringari C, Orozco-Solis R, Gratton E, Sassone-Corsi P
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 8;113(45):12715-12720
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 8;113(45):12715-12720
NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration.
Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S
Molecular and cellular biology 2016 May;36(9):1383-94
Molecular and cellular biology 2016 May;36(9):1383-94
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR, Burstein E
Nature immunology 2016 May;17(5):495-504
Nature immunology 2016 May;17(5):495-504
Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells.
Gordillo GM, Biswas A, Khanna S, Spieldenner JM, Pan X, Sen CK
The Journal of biological chemistry 2016 May 6;291(19):10089-103
The Journal of biological chemistry 2016 May 6;291(19):10089-103
Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
Chinnam M, Wang X, Zhang X, Goodrich DW
Molecular and cellular biology 2016 Jun 1;36(11):1621-7
Molecular and cellular biology 2016 Jun 1;36(11):1621-7
Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β.
Saud SM, Li W, Gray Z, Matter MS, Colburn NH, Young MR, Kim YS
Cancer prevention research (Philadelphia, Pa.) 2016 Jul;9(7):607-15
Cancer prevention research (Philadelphia, Pa.) 2016 Jul;9(7):607-15
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.
Marceau CD, Puschnik AS, Majzoub K, Ooi YS, Brewer SM, Fuchs G, Swaminathan K, Mata MA, Elias JE, Sarnow P, Carette JE
Nature 2016 Jul 7;535(7610):159-63
Nature 2016 Jul 7;535(7610):159-63
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.
Marina RJ, Sturgill D, Bailly MA, Thenoz M, Varma G, Prigge MF, Nanan KK, Shukla S, Haque N, Oberdoerffer S
The EMBO journal 2016 Feb 1;35(3):335-55
The EMBO journal 2016 Feb 1;35(3):335-55
IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation.
Kang K, Won M, Yuk JM, Park CY, Byun HS, Park KA, Lee SR, Kang YG, Shen HM, Lee IY, Hur GM
Biochemical pharmacology 2016 Dec 1;121:52-66
Biochemical pharmacology 2016 Dec 1;121:52-66
ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.
Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG
Molecular cell 2016 Aug 4;63(3):470-84
Molecular cell 2016 Aug 4;63(3):470-84
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV
Nature communications 2016 Apr 5;7:11240
Nature communications 2016 Apr 5;7:11240
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Zhu J, Chen H, Guo XE, Qiu XL, Hu CM, Chamberlin AR, Lee WH
European journal of medicinal chemistry 2015;96:196-208
European journal of medicinal chemistry 2015;96:196-208
A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma.
Ip JC, Ko JM, Yu VZ, Chan KW, Lam AK, Law S, Tong DK, Lung ML
BioMed research international 2015;2015:910715
BioMed research international 2015;2015:910715
The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
Ghosh M, Aguirre V, Wai K, Felfly H, Dietrich WD, Pearse DD
BioMed research international 2015;2015:308461
BioMed research international 2015;2015:308461
Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.
Corbett L, Mann J, Mann DA
PloS one 2015;10(11):e0142794
PloS one 2015;10(11):e0142794
Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.
Ho SR, Lee YJ, Lin WC
The Journal of biological chemistry 2015 Sep 18;290(38):23026-38
The Journal of biological chemistry 2015 Sep 18;290(38):23026-38
Endothelial cell tumor growth is Ape/ref-1 dependent.
Biswas A, Khanna S, Roy S, Pan X, Sen CK, Gordillo GM
American journal of physiology. Cell physiology 2015 Sep 1;309(5):C296-307
American journal of physiology. Cell physiology 2015 Sep 1;309(5):C296-307
Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).
Desai SS, Kharade SS, Parekh VI, Iyer S, Agarwal SK
The Journal of biological chemistry 2015 Oct 16;290(42):25595-608
The Journal of biological chemistry 2015 Oct 16;290(42):25595-608
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y, Fernández-Hernando C
Nature medicine 2015 Nov;21(11):1280-9
Nature medicine 2015 Nov;21(11):1280-9
Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.
Bowman J, Rodgers MA, Shi M, Amatya R, Hostager B, Iwai K, Gao SJ, Jung JU
mBio 2015 Nov 17;6(6):e01777-15
mBio 2015 Nov 17;6(6):e01777-15
Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.
Verweij MC, Wellish M, Whitmer T, Malouli D, Lapel M, Jonjić S, Haas JG, DeFilippis VR, Mahalingam R, Früh K
PLoS pathogens 2015 May;11(5):e1004901
PLoS pathogens 2015 May;11(5):e1004901
Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells.
Puebla-Osorio N, Damiani E, Bover L, Ullrich SE
Cell death & disease 2015 May 7;6:e1745
Cell death & disease 2015 May 7;6:e1745
Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome.
Albert JS, Bhattacharyya N, Wolfe LA, Bone WP, Maduro V, Accardi J, Adams DR, Schwartz CE, Norris J, Wood T, Gafni RI, Collins MT, Tosi LL, Markello TC, Gahl WA, Boerkoel CF
Orphanet journal of rare diseases 2015 Mar 7;10:27
Orphanet journal of rare diseases 2015 Mar 7;10:27
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L
PLoS genetics 2015 Jul;11(7):e1005410
PLoS genetics 2015 Jul;11(7):e1005410
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Patel JP, Puck JM, Srinivasan R, Brown C, Sunderam U, Kundu K, Brenner SE, Gatti RA, Church JA
Journal of clinical immunology 2015 Feb;35(2):227-33
Journal of clinical immunology 2015 Feb;35(2):227-33
Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells.
Damiani E, Puebla-Osorio N, Gorbea E, Ullrich SE
The Journal of investigative dermatology 2015 Dec;135(12):3034-3040
The Journal of investigative dermatology 2015 Dec;135(12):3034-3040
USP7 cooperates with SCML2 to regulate the activity of PRC1.
Lecona E, Narendra V, Reinberg D
Molecular and cellular biology 2015 Apr;35(7):1157-68
Molecular and cellular biology 2015 Apr;35(7):1157-68
The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.
Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC
Molecular and cellular biology 2015 Apr;35(7):1125-38
Molecular and cellular biology 2015 Apr;35(7):1125-38
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
Aguilar-Arnal L, Katada S, Orozco-Solis R, Sassone-Corsi P
Nature structural & molecular biology 2015 Apr;22(4):312-8
Nature structural & molecular biology 2015 Apr;22(4):312-8
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.
Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V
PLoS pathogens 2015 Apr;11(4):e1004818
PLoS pathogens 2015 Apr;11(4):e1004818
RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.
Li M, Pokharel S, Wang JT, Xu X, Liu Y
Nature communications 2015 Apr 8;6:6720
Nature communications 2015 Apr 8;6:6720
The Thoc1 ribonucleoprotein and prostate cancer progression.
Chinnam M, Wang Y, Zhang X, Gold DL, Khoury T, Nikitin AY, Foster BA, Li Y, Bshara W, Morrison CD, Payne Ondracek RD, Mohler JL, Goodrich DW
Journal of the National Cancer Institute 2014 Nov;106(11)
Journal of the National Cancer Institute 2014 Nov;106(11)
Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.
Wang JT, Xu X, Alontaga AY, Chen Y, Liu Y
Cell reports 2014 May 8;7(3):848-58
Cell reports 2014 May 8;7(3):848-58
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, Wappner P, Schofield CJ, Ratcliffe PJ, Cockman ME
Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 18;111(11):4031-6
Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 18;111(11):4031-6
RNA binding protein HuR regulates the expression of ABCA1.
Ramírez CM, Lin CS, Abdelmohsen K, Goedeke L, Yoon JH, Madrigal-Matute J, Martin-Ventura JL, Vo DT, Uren PJ, Penalva LO, Gorospe M, Fernández-Hernando C
Journal of lipid research 2014 Jun;55(6):1066-76
Journal of lipid research 2014 Jun;55(6):1066-76
ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling.
Nikolos F, Thomas C, Rajapaksa G, Bado I, Gustafsson JÅ
Molecular cancer research : MCR 2014 Jun;12(6):843-54
Molecular cancer research : MCR 2014 Jun;12(6):843-54
Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment.
Chen Y, Chen CF, Polci R, Wei R, Riley DJ, Chen PL
Oncotarget 2014 Jun 30;5(12):4283-94
Oncotarget 2014 Jun 30;5(12):4283-94
A-T : Pathogenesis of rare missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity
Nakamura K, Fike F, Haghayegh S, Saunders-Pullman R, Dawson A, Dörk T, Gatti R
Molecular Genetics & Genomic Medicine 2014 July;2(4):332-340
Molecular Genetics & Genomic Medicine 2014 July;2(4):332-340
Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice.
Lazic M, Eguchi A, Berk MP, Povero D, Papouchado B, Mulya A, Johnson CD, Feldstein AE
Journal of hepatology 2014 Jul;61(1):107-15
Journal of hepatology 2014 Jul;61(1):107-15
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Nakamura K, Fike F, Haghayegh S, Saunders-Pullman R, Dawson AJ, Dörk T, Gatti RA
Molecular genetics & genomic medicine 2014 Jul;2(4):332-40
Molecular genetics & genomic medicine 2014 Jul;2(4):332-40
Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.
Chen Y, Chiang HC, Litchfield P, Pena M, Juang C, Riley DJ
Journal of biomedical science 2014 Jul 17;21:63
Journal of biomedical science 2014 Jul 17;21:63
TRAF2 facilitates vaccinia virus replication by promoting rapid virus entry.
Haga IR, Pechenick Jowers T, Griffiths SJ, Haas J, Beard PM
Journal of virology 2014 Apr;88(7):3664-77
Journal of virology 2014 Apr;88(7):3664-77
HIF1-α-mediated gene expression induced by vitamin B1 deficiency.
Sweet RL, Zastre JA
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2013;83(3):188-97
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2013;83(3):188-97
Functional Integration of the Conserved Domains of Shoc2 Scaffold.
Jeoung M, Abdelmoti L, Jang ER, Vander Kooi CW, Galperin E
PloS one 2013;8(6):e66067
PloS one 2013;8(6):e66067
The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance.
Chow AK, Ng L, Lam CS, Wong SK, Wan TM, Cheng NS, Yau TC, Poon RT, Pang RW
PloS one 2013;8(11):e78675
PloS one 2013;8(11):e78675
The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.
Pitzonka L, Wang X, Ullas S, Wolff DW, Wang Y, Goodrich DW
Molecular and cellular biology 2013 Sep;33(17):3505-14
Molecular and cellular biology 2013 Sep;33(17):3505-14
Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line.
Sharma M, Salisbury RL, Maurer EI, Hussain SM, Sulentic CE
Nanoscale 2013 May 7;5(9):3747-56
Nanoscale 2013 May 7;5(9):3747-56
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH
EMBO molecular medicine 2013 Mar;5(3):353-65
EMBO molecular medicine 2013 Mar;5(3):353-65
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.
Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S, Gustafsson ÅB
Genes & development 2013 Jun 15;27(12):1365-77
Genes & development 2013 Jun 15;27(12):1365-77
A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM
Nature cell biology 2013 Dec;15(12):1473-85
Nature cell biology 2013 Dec;15(12):1473-85
Reprogramming of the circadian clock by nutritional challenge.
Eckel-Mahan KL, Patel VR, de Mateo S, Orozco-Solis R, Ceglia NJ, Sahar S, Dilag-Penilla SA, Dyar KA, Baldi P, Sassone-Corsi P
Cell 2013 Dec 19;155(7):1464-78
Cell 2013 Dec 19;155(7):1464-78
DSIF restricts NF-κB signaling by coordinating elongation with mRNA processing of negative feedback genes.
Diamant G, Amir-Zilberstein L, Yamaguchi Y, Handa H, Dikstein R
Cell reports 2012 Oct 25;2(4):722-31
Cell reports 2012 Oct 25;2(4):722-31
Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors.
Kanungo J, Chandrasekharappa SC
Molecular and cellular biochemistry 2012 Jan;359(1-2):95-104
Molecular and cellular biochemistry 2012 Jan;359(1-2):95-104
A physiological role for androgen actions in the absence of androgen receptor DNA binding activity.
Pang TP, Clarke MV, Ghasem-Zadeh A, Lee NK, Davey RA, MacLean HE
Molecular and cellular endocrinology 2012 Jan 2;348(1):189-97
Molecular and cellular endocrinology 2012 Jan 2;348(1):189-97
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH
Molecular cell 2012 Dec 14;48(5):747-59
Molecular cell 2012 Dec 14;48(5):747-59
Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.
Nini L, Zhang JH, Pandey M, Panicker LM, Simonds WF
Endocrine 2012 Aug;42(1):214-7
Endocrine 2012 Aug;42(1):214-7
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T
RNA (New York, N.Y.) 2011 Nov;17(11):1957-66
RNA (New York, N.Y.) 2011 Nov;17(11):1957-66
The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, Agarwal SK, Marx SJ
Cancer research 2011 Jan 15;71(2):371-82
Cancer research 2011 Jan 15;71(2):371-82
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Chen Y, Chen CF, Riley DJ, Chen PL
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Chen Y, Chen CF, Riley DJ, Chen PL
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
Lee SK, Chung JI, Park MS, Joo HK, Lee EJ, Cho EJ, Park JB, Ryoo S, Irani K, Jeon BH
Cardiovascular research 2011 Aug 1;91(3):502-9
Cardiovascular research 2011 Aug 1;91(3):502-9
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Färber S, Koch A, Jaworska E, Spooncer E, Gruber AD, Whetton AD, Tamura T
BMC biology 2010 Jan 5;8:1
BMC biology 2010 Jan 5;8:1
Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.
Wang X, Chinnam M, Wang J, Wang Y, Zhang X, Marcon E, Moens P, Goodrich DW
Molecular and cellular biology 2009 May;29(10):2794-803
Molecular and cellular biology 2009 May;29(10):2794-803
Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).
El Bounkari O, Guria A, Klebba-Faerber S, Claussen M, Pieler T, Griffiths JR, Whetton AD, Koch A, Tamura T
FEBS letters 2009 Jan 5;583(1):13-8
FEBS letters 2009 Jan 5;583(1):13-8
Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer.
Yang J, Li Y, Khoury T, Alrawi S, Goodrich DW, Tan D
Annals of clinical and laboratory science 2008 Spring;38(2):105-12
Annals of clinical and laboratory science 2008 Spring;38(2):105-12
Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes.
Byun HS, Song JK, Kim YR, Piao L, Won M, Park KA, Choi BL, Lee H, Hong JH, Park J, Seok JH, Lee YJ, Kang SW, Hur GM
Rheumatology (Oxford, England) 2008 Mar;47(3):301-8
Rheumatology (Oxford, England) 2008 Mar;47(3):301-8
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
Bhandari R, Juluri KR, Resnick AC, Snyder SH
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 19;105(7):2349-53
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 19;105(7):2349-53
R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
Nini L, Waheed AA, Panicker LM, Czapiga M, Zhang JH, Simonds WF
BMC biochemistry 2007 Sep 19;8:18
BMC biochemistry 2007 Sep 19;8:18
Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genes.
Ji Y, Prasad NB, Novotny EA, Kaur S, Elkahloun A, Chen Y, Zhang RZ, Chu ML, Agarwal SK, Marx SJ, Collins FS, Chandrasekharappa SC
Molecular cancer research : MCR 2007 Oct;5(10):1041-51
Molecular cancer research : MCR 2007 Oct;5(10):1041-51
Cancer cells and normal cells differ in their requirements for Thoc1.
Li Y, Lin AW, Zhang X, Wang Y, Wang X, Goodrich DW
Cancer research 2007 Jul 15;67(14):6657-64
Cancer research 2007 Jul 15;67(14):6657-64
Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
Birle DC, Hedley DW
Cancer research 2007 Feb 15;67(4):1735-43
Cancer research 2007 Feb 15;67(4):1735-43
FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Mancini A, El Bounkari O, Norrenbrock AF, Scherr M, Schaefer D, Eder M, Banham AH, Pulford K, Lyne L, Whetton AD, Tamura T
Oncogene 2007 Feb 15;26(7):1020-7
Oncogene 2007 Feb 15;26(7):1020-7
Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.
Wang X, Chang Y, Li Y, Zhang X, Goodrich DW
Molecular and cellular biology 2006 Jun;26(11):4362-7
Molecular and cellular biology 2006 Jun;26(11):4362-7
Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.
Li Y, Wang X, Zhang X, Goodrich DW
Molecular and cellular biology 2005 May;25(10):4023-33
Molecular and cellular biology 2005 May;25(10):4023-33
The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.
Gasparri F, Sola F, Locatelli G, Muzio M
FEBS letters 2004 Sep 10;574(1-3):13-9
FEBS letters 2004 Sep 10;574(1-3):13-9
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.
Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, Burns AL, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10770-5
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10770-5
Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier.
Jaubert J, Cheng J, Segre JA
Development (Cambridge, England) 2003 Jun;130(12):2767-77
Development (Cambridge, England) 2003 Jun;130(12):2767-77
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Sukhodolets KE, Hickman AB, Agarwal SK, Sukhodolets MV, Obungu VH, Novotny EA, Crabtree JS, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ
Molecular and cellular biology 2003 Jan;23(2):493-509
Molecular and cellular biology 2003 Jan;23(2):493-509
Novel N-terminal variant of human VDR.
Sunn KL, Cock TA, Crofts LA, Eisman JA, Gardiner EM
Molecular endocrinology (Baltimore, Md.) 2001 Sep;15(9):1599-609
Molecular endocrinology (Baltimore, Md.) 2001 Sep;15(9):1599-609
Characterization of the mouse JAB1 cDNA and protein.
Bounpheng MA, Melnikova IN, Dodds SG, Chen H, Copeland NG, Gilbert DJ, Jenkins NA, Christy BA
Gene 2000 Jan 25;242(1-2):41-50
Gene 2000 Jan 25;242(1-2):41-50
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Supportive validation
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- p84 antibody [5E10] detects p84 protein by western blot analysis.A. 30 ?g 293T whole cell lysate/extractB. 30 ?g A431 whole cell lysate/extractC. 30 ?g HeLa whole cell lysate/extractD. 30 ?g HepG2 whole cell lysate/extractE. 30 ?g A375 whole cell lysate/extract7.5% SDS-PAGEp84 antibody [5E10] (GTX70220) dilution: 1:500The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Detection of human p84/N5 in nuclear fraction by anti-p84/N5 5E10 monoclonal antibody (GTX70220) in western blot experiment. Lane 1: total lysate, Lane 2: cytoplasmic fraction, Lane 3: membrane fraction, Lane 4: nuclear fraction.
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- Sample (30 ?g of whole cell lysate) A: HeLa B: HeLa nucleus 7.5% SDS PAGE GTX70220 diluted at 1:1000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Sample (whole cell lysate) A: 293T 20ug B: 293T 10ug C: 293T 5ug 7.5% SDS PAGE GTX70220 diluted at 1:1000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Sample (50 ?g of whole cell lysate) A: mouse Cerebellum 7.5% SDS PAGE GTX70220 diluted at 1:1000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Sample (30 ug of whole cell lysate) A: Jurkat B: Raji C: 293T D: A431 E: HeLa F: HepG2 G: H1299 H: HCT116 I: MCF-7 J: NT2D1 K: PC-3 L: U87-MG 7.5% SDS PAGE GTX70220 diluted at 1:1000
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- WB
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- Sample (30 ?g of whole cell lysate) A: 293T B: NIH-3T3 C: mouse brain D: PC-12 7.5% SDS PAGE GTX70220 diluted at 1:1000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Sample (30 ug of cell lysate) A: HeLa B: HeLa cytosol fraction C: HeLa nucleus fraction 7.5% SDS PAGE GTX70220 diluted at 1:1000
- Validation comment
- WB
Supportive validation
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- p84 antibody [5E10] detects p84 protein at nucleus by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: p84 protein stained by p84 antibody [5E10] (GTX70220) diluted at 1:500.Red: phalloidin, a cytoskeleton marker, stained by phalloidin (invitrogen, A12380) diluted at 1:200.
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- Nuclear Matrix Protein p84 antibody [5E10] detects Nuclear Matrix Protein p84 protein at nucleus by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: Nuclear Matrix Protein p84 stained by Nuclear Matrix Protein p84 antibody [5E10] (GTX70220) diluted at 1:500.Red: phalloidin, a cytoskeleton? marker, diluted at 1:100.
Supportive validation
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- p84 antibody [5E10] immunoprecipitates p84 protein in IP experiments. IP Sample: HepG2 whole cell lysate/extract A : 30 £gg whole cell lysate/extract of p84 protein expressing HepG2 cells B : Control with 3 £gg of pre-immune mouse IgG C : Immunoprecipitation of p84 by 3 £gg of p84 antibody [5E10] (GTX70220) 7.5% SDS-PAGE The immunoprecipitated p84 protein was detected by p84 antibody [5E10] (GTX70220) diluted at 1 : 1000. EasyBlot anti-rabbit IgG (HRP) (GTX221667-01) was used as a secondary reagent.
