FNab04429

antibody from FineTest Biotech

Targeting: IWS1 DKFZp761G0123, FLJ10006, FLJ14655, FLJ32319

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ELISA

Immunoprecipitation

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Validation data

Product number: FNab04429 - Provider product page
Provider: FineTest Biotech
Product name: IWS1 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: IWS1 homolog
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

IWS1 protein structure - FNab04429 shown in red.