orb2635091

antibody from Biorbyt
Targeting: MEF2B RSRFR2
Provider product page for orb2635091
Western blot
Immunocytochemistry
Flow cytometry

Antibody data

Product number
orb2635091 - Provider product page
Provider
Biorbyt
Product name
MEF2B Antibody
Antibody type
Monoclonal
Description
The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
PCRP-MEF2B-2F9
Vial size
20 ug
Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
MEF2B protein structure - orb2635091 shown in red.