CABT-RM174

antibody from Creative Diagnostics

Targeting: AQP11

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-RM174

Provider

Creative Diagnostics

Product name

Mouse Anti-KLC monoclonal antibody, clone 74-00

Antibody type

Monoclonal

Description

Kinesin light chain is encoded by the Klc1/Klc2 gene in rat. Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The kinesin light chain (KLC) may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Kinesin light chain 1 is expressed in the brain tissue and exists as an oligomeric complex of two heavy and two light chains. It also contains six tetratricopeptide repeats (TPR). The heavy chains of kinesin have a microtubule-binding ATPase motor domain at their amino terminus, a neck coil, and an extended series of coiled coils, separated by a hinge region, that results in heavy-chain dimerization. Kinesin light chains can associate with the heavy-chain coiled coils at the carboxyl-terminal region. The light chains bind cargoes and regulate its activity. KLCs through their TRP repeat domains can recognize shirt linear peptide motifs found on cargo proteins. In the absence of any cargo binding, kinesin-1 exists in a folded compact state, which prevents unnecessary cycles of ATP hydrolysis. However, in the cargo-bound active state inhibition is relieved and it adopts a more elongated structure that can hydrolyze ATP and translocate along microtubules. Point mutations in Klc gene can affect functional domains in kinesin, which can result in late-onset dying-back neuropathies in sensory or motor neurons.

Reactivity

Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG