CAPN12

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]

Description

Calpain 12

Tissue specificity

Group enriched (gallbladder, liver)

Subcell location

Nucleoplasm, Focal adhesion sites

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (38730187 - 38769904)

Ensembl ID

ENSG00000182472  (ver. 103.38)

Orthologs

Mouse Capn12: ENSMUSG00000054083

UniProt

Q6ZSI9

neXtProt

NX_Q6ZSI9

Human splice variants
Mouse splice variants

Protein structure