Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8794 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SETD6 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- N-lysine methyltransferase SETD6; SET domain-containing protein 6; SETD6
- Description
- SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates ¡ùLys-310¡ì of the NF°ÙB p65 subunit of NF°ÙB complex, leading to down-regulate NF°ÙB transcription factor activity. SETD6-mediated methylation renders NF°ÙB p65 inert and attenuates NF°ÙB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NF°ÙB-mediated inflammatory responses in diverse cell types.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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