BS8794

antibody from Bioworld Technology, Inc
Targeting: SETD6 FLJ21148
Provider product page for BS8794
Western blot
Immunohistochemistry

Antibody data

Product number
BS8794 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SETD6 polyclonal antibody
Antibody type
Polyclonal
Antigen
N-lysine methyltransferase SETD6; SET domain-containing protein 6; SETD6
Description
SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates ¡ùLys-310¡ì of the NF°ÙB p65 subunit of NF°ÙB complex, leading to down-regulate NF°ÙB transcription factor activity. SETD6-mediated methylation renders NF°ÙB p65 inert and attenuates NF°ÙB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NF°ÙB-mediated inflammatory responses in diverse cell types.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SETD6 protein structure - BS8794 shown in red.