FGD4

gene product
CMT4H, frabin, FRABP, ZFYVE6
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
100 antibodies from 18 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
2 antibodies
antibodies-online
38 antibodies
Novus Biologicals
4 antibodies
LifeSpan BioSciences, Inc.
18 antibodies
OriGene
3 antibodies
Biorbyt
9 antibodies
Aviva Systems Biology
2 antibodies
GeneTex
2 antibodies
Signalway Antibody LLC
1 antibody
Abnova Corporation
1 antibody
Atlas Antibodies
1 antibody
RabMAbs
1 antibody
Acris Antibodies GmbH
1 antibody
MyBioSource
1 antibody
St John's Laboratory
1 antibody
United States Biological
13 antibodies
Creative Diagnostics
1 antibody
ProSci
1 antibody