DPABH-09117

antibody from Creative Diagnostics

Targeting: FGD4 CMT4H, frabin, FRABP, ZFYVE6

Western blot (Recommended by provider)

Antibody Data

Product number

DPABH-09117

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-09117, RRID:AB_2522909

Product name

Rabbit Anti-Human FGD4 Polyclonal Antibody

Antibody type

Polyclonal

Description

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

50ul, 100ul

Storage

Store at -20°C. Avoid freeze / thaw cycles.