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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Flow cytometry [1]
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- Product number
- 48-3379-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD337 (NKp30) Monoclonal Antibody (AF29-4D12), eFluor™ 450, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This AF29-4D12 monoclonal antibody reacts with human CD337, which is also known as NKp30. Expressed on NK cells, CD337 is the predominant member of the natural cytotoxicity receptor family that also includes NKp46 and NKp44. CD337 is involved in activating and expanding resting NK cells following interaction with dendritic cells to eliminate tumor, virus-infected, and immature dendritic cells. Several ligands for this receptor have been reported, including B7-H6.
- Antibody clone number
- AF29-4D12
- Concentration
- 5 µL/Test
Submitted references Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity.
Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients.
A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.
Fully functional NK cells after unrelated cord blood transplantation.
Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.
Kellner C, Maurer T, Hallack D, Repp R, van de Winkel JG, Parren PW, Valerius T, Humpe A, Gramatzki M, Peipp M
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 15;189(10):5037-46
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 15;189(10):5037-46
Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients.
Sanchez-Correa B, Gayoso I, Bergua JM, Casado JG, Morgado S, Solana R, Tarazona R
Immunology and cell biology 2012 Jan;90(1):109-15
Immunology and cell biology 2012 Jan;90(1):109-15
A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
Vargas-Inchaustegui DA, Demberg T, Robert-Guroff M
Immunology 2011 Nov;134(3):326-40
Immunology 2011 Nov;134(3):326-40
Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.
Joyce MG, Tran P, Zhuravleva MA, Jaw J, Colonna M, Sun PD
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 12;108(15):6223-8
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 12;108(15):6223-8
Fully functional NK cells after unrelated cord blood transplantation.
Beziat V, Nguyen S, Lapusan S, Hervier B, Dhedin N, Bories D, Uzunov M, Boudifa A, Trebeden-Negre H, Norol F, Marjanovic Z, Marie JP, Vernant JP, Debre P, Rio B, Vieillard V
Leukemia 2009 Apr;23(4):721-8
Leukemia 2009 Apr;23(4):721-8
Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.
Pende D, Parolini S, Pessino A, Sivori S, Augugliaro R, Morelli L, Marcenaro E, Accame L, Malaspina A, Biassoni R, Bottino C, Moretta L, Moretta A
The Journal of experimental medicine 1999 Nov 15;190(10):1505-16
The Journal of experimental medicine 1999 Nov 15;190(10):1505-16
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD56 (NCAM) APC (Product # 17-0567-42) and Mouse IgG1 K Isotype Control eFluor® 450 (Product # 48-4714-82) (left) or Anti-Human CD337 (NKp30) eFluor® 450 (right). Cells in the lymphocyte gate were used for analysis.
