Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 325204 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#325204, RRID:AB_756108
- Product name
- LEAF™ purified anti-human CD337 (NKp30) [P30-15]
- Antibody type
- Monoclonal
- Antigen
- Recombinant human NKp30
- Description
- The p30-15 monoclonal antibody recognizes CD337 also known as activating NK receptor NKp30 (NKp30), and natural cytotoxicity triggering receptor 3. NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on resting and activated NK cells. NKp30 enhances NK cell cytolysis of tumor cellts that are deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ. The p30-15 antibody against human NKp30 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp30 in a redirected lysis assay, and blocking of NKp30 function in solution.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Endometrial NK cells are special immature cells that await pregnancy.
Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1869-76
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1869-76
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood lymphocytes stained with LEAF™ purified P30-15, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated