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- Antigen structure
- References [19]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 12990-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12990-1-AP, RRID:AB_2164342
- Product name
- PGRMC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PGRMC1 antibody (Cat. #12990-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling.
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling.
Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells.
Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo.
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells.
PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes.
Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival.
A potential mechanism underlying atypical antipsychotics-induced lipid disturbances.
The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.
Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
Hyaluronic acid promotes the expression of progesterone receptor membrane component 1 via epigenetic silencing of miR-139-5p in human and rat granulosa cells.
Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients.
Evidence for a genomic mechanism of action for progesterone receptor membrane component-1.
Scientific Program Schedule 57th Annual Scientific Meeting.
Reproductive sciences (Thousand Oaks, Calif.) 2010 Mar;17(3_suppl):25
Zeng C, Chen H, Cao T, Wang L, Jiao S, Lin C, Zhang B, Cai H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114490
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114490
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Cao T, Wang L, Jiao S, Chen H, Lin C, Zhang B, Cai H
Neuropsychobiology 2023;82(6):346-358
Neuropsychobiology 2023;82(6):346-358
Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling.
Zhu Z, Cao T, Chen H, Zhang B, Lin C, Cai H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113757
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113757
Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells.
Wang L, Chen Q, Ma R, Zhang B, Yang P, Cao T, Jiao S, Chen H, Lin C, Cai H
Toxicology 2023 Jun 1;491:153515
Toxicology 2023 Jun 1;491:153515
Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo.
He Y, Dong XH, Zhu Q, Xu YL, Chen ML, Liu Z
Military Medical Research 2022 Feb 14;9(1):9
Military Medical Research 2022 Feb 14;9(1):9
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Cao T, Chen Q, Zhang B, Wu X, Zeng C, Zhang S, Cai H
Frontiers in endocrinology 2021;12:727371
Frontiers in endocrinology 2021;12:727371
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells.
Intlekofer KA, Clements K, Woods H, Adams H, Suvorov A, Petersen SL
PloS one 2019;14(4):e0215389
PloS one 2019;14(4):e0215389
PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes.
Terzaghi L, Luciano AM, Dall'Acqua PC, Modina SC, Peluso JJ, Lodde V
Reproduction (Cambridge, England) 2018 Mar;155(3):273-282
Reproduction (Cambridge, England) 2018 Mar;155(3):273-282
Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.
Yuan XH, Yang CR, Wang XN, Zhang LL, Gao XR, Shi ZY
Journal of cellular physiology 2018 Jan;234(1):709-720
Journal of cellular physiology 2018 Jan;234(1):709-720
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
Latosinska A, Mokou M, Makridakis M, Mullen W, Zoidakis J, Lygirou V, Frantzi M, Katafigiotis I, Stravodimos K, Hupe MC, Dobrzynski M, Kolch W, Merseburger AS, Mischak H, Roubelakis MG, Vlahou A
Oncotarget 2017 Sep 19;8(41):69435-69455
Oncotarget 2017 Sep 19;8(41):69435-69455
PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival.
Hampton KK, Stewart R, Napier D, Claudio PP, Craven RJ
Advances in lung cancer (Irvine) 2015 Sep;4(3):37-51
Advances in lung cancer (Irvine) 2015 Sep;4(3):37-51
A potential mechanism underlying atypical antipsychotics-induced lipid disturbances.
Cai HL, Tan QY, Jiang P, Dang RL, Xue Y, Tang MM, Xu P, Deng Y, Li HD, Yao JK
Translational psychiatry 2015 Oct 20;5(10):e661
Translational psychiatry 2015 Oct 20;5(10):e661
The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.
Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE
EBioMedicine 2015 Nov;2(11):1806-13
EBioMedicine 2015 Nov;2(11):1806-13
Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
Zhao G, Yan G, Cheng J, Zhou X, Fang T, Sun H, Hou Y, Hu Y
Scientific reports 2015 Jan 6;5:7647
Scientific reports 2015 Jan 6;5:7647
Hyaluronic acid promotes the expression of progesterone receptor membrane component 1 via epigenetic silencing of miR-139-5p in human and rat granulosa cells.
Zhao G, Zhou X, Fang T, Hou Y, Hu Y
Biology of reproduction 2014 Nov;91(5):116
Biology of reproduction 2014 Nov;91(5):116
Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients.
Mir SU, Ahmed IS, Arnold S, Craven RJ
International journal of cancer 2012 Jul 15;131(2):E1-9
International journal of cancer 2012 Jul 15;131(2):E1-9
Evidence for a genomic mechanism of action for progesterone receptor membrane component-1.
Peluso JJ, DeCerbo J, Lodde V
Steroids 2012 Aug;77(10):1007-12
Steroids 2012 Aug;77(10):1007-12
Scientific Program Schedule 57th Annual Scientific Meeting.
Reproductive sciences (Thousand Oaks, Calif.) 2010 Mar;17(3_suppl):25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 12990-1-AP(PGRMC1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-PGRMC1 (IP:12990-1-AP, 3ug; Detection:12990-1-AP 1:1000) with MCF-7 cells lysate 1600ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PGRMC1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PGRMC1. This antibody recognizes human,mouse,rat antigen. The PGRMC1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
