Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 16413-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16413-1-AP, RRID:AB_2714217
- Product name
- SMCR7/MID49 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMCR7/MID49 antibody (Cat. #16413-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics.
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division.
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability.
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity.
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption.
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Huangqi-Danshen Decoction Ameliorates Adenine-Induced Chronic Kidney Disease by Modulating Mitochondrial Dynamics.
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis.
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1.
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2.
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling.
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Loss of Yme1L perturbates mitochondrial dynamics.
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP
The Journal of biological chemistry 2021 Oct;297(4):101196
The Journal of biological chemistry 2021 Oct;297(4):101196
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
Nie T, Tao K, Zhu L, Huang L, Hu S, Yang R, Xu P, Mao Z, Yang Q
Autophagy 2021 Oct;17(10):2923-2938
Autophagy 2021 Oct;17(10):2923-2938
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Axelrod CL, Fealy CE, Erickson ML, Davuluri G, Fujioka H, Dantas WS, Huang E, Pergola K, Mey JT, King WT, Mulya A, Hsia D, Burguera B, Tandler B, Hoppel CL, Kirwan JP
Metabolism: clinical and experimental 2021 Aug;121:154803
Metabolism: clinical and experimental 2021 Aug;121:154803
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Feng X, Wang S, Yang X, Lin J, Man W, Dong Y, Zhang Y, Zhao Z, Wang H, Sun D
Frontiers in cell and developmental biology 2020;8:628842
Frontiers in cell and developmental biology 2020;8:628842
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division.
Nagashima S, Tábara LC, Tilokani L, Paupe V, Anand H, Pogson JH, Zunino R, McBride HM, Prudent J
Science (New York, N.Y.) 2020 Mar 20;367(6484):1366-1371
Science (New York, N.Y.) 2020 Mar 20;367(6484):1366-1371
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Tokuyama T, Hirai A, Shiiba I, Ito N, Matsuno K, Takeda K, Saito K, Mii K, Matsushita N, Fukuda T, Inatome R, Yanagi S
Biomolecules 2020 Mar 13;10(3)
Biomolecules 2020 Mar 13;10(3)
NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability.
Chen CW, Tsao N, Zhang W, Chang ZF
International journal of molecular sciences 2020 Jul 17;21(14)
International journal of molecular sciences 2020 Jul 17;21(14)
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
Zhou BH, Wei SS, Jia LS, Zhang Y, Miao CY, Wang HW
The Science of the total environment 2020 Jul 10;725:138192
The Science of the total environment 2020 Jul 10;725:138192
The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity.
Yasukawa K, Kinoshita D, Yaku K, Nakagawa T, Koshiba T
The Journal of biological chemistry 2020 Jan 10;295(2):444-457
The Journal of biological chemistry 2020 Jan 10;295(2):444-457
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Murata D, Yamada T, Tokuyama T, Arai K, Quirós PM, López-Otín C, Iijima M, Sesaki H
The EMBO journal 2020 Dec 15;39(24):e105074
The EMBO journal 2020 Dec 15;39(24):e105074
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF
Cell death and differentiation 2020 Aug;27(8):2484-2499
Cell death and differentiation 2020 Aug;27(8):2484-2499
Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption.
Sivakumar A, Shanmugarajan S, Subbiah R, Balakrishnan R
Apoptosis : an international journal on programmed cell death 2020 Aug;25(7-8):590-604
Apoptosis : an international journal on programmed cell death 2020 Aug;25(7-8):590-604
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK
PLoS biology 2020 Aug;18(8):e3000808
PLoS biology 2020 Aug;18(8):e3000808
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Bai L, Liang J, Li L, Li E
Oncology reports 2020 Apr;43(4):1208-1220
Oncology reports 2020 Apr;43(4):1208-1220
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Dasgupta A, Chen KH, Wu D, Hoskin V, Mewburn J, Lima PDA, Parlow LRG, Hindmarch CCT, Martin A, Sykes EA, Tayade C, Lightbody ED, Madarnas Y, SenGupta SK, Elliott BE, Nicol CJB, Archer SL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5106-5127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5106-5127
Huangqi-Danshen Decoction Ameliorates Adenine-Induced Chronic Kidney Disease by Modulating Mitochondrial Dynamics.
Liu X, Huang S, Wang F, Zheng L, Lu J, Chen J, Li S
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9574045
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9574045
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
Lee L, Seager R, Nakamura Y, Wilkinson KA, Henley JM
PloS one 2019;14(5):e0213116
PloS one 2019;14(5):e0213116
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Xian H, Yang Q, Xiao L, Shen HM, Liou YC
Nature communications 2019 May 3;10(1):2059
Nature communications 2019 May 3;10(1):2059
Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis.
Yedida G, Milani M, Cohen GM, Varadarajan S
Cell death & disease 2019 Jul 8;10(7):521
Cell death & disease 2019 Jul 8;10(7):521
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):566-574
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):566-574
Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1.
Geng J, Liu W, Gao J, Jiang C, Fan T, Sun Y, Qin ZH, Xu Q, Guo W, Gao J
British journal of pharmacology 2019 Dec;176(23):4574-4591
British journal of pharmacology 2019 Dec;176(23):4574-4591
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Nagashima S, Takeda K, Ohno N, Ishido S, Aoki M, Saitoh Y, Takada T, Tokuyama T, Sugiura A, Fukuda T, Matsushita N, Inatome R, Yanagi S
Life science alliance 2019 Aug;2(4)
Life science alliance 2019 Aug;2(4)
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.
Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL
Frontiers in cardiovascular medicine 2018;5:195
Frontiers in cardiovascular medicine 2018;5:195
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies.
Bartsakoulia M, Pyle A, Troncoso-Chandía D, Vial-Brizzi J, Paz-Fiblas MV, Duff J, Griffin H, Boczonadi V, Lochmüller H, Kleinle S, Chinnery PF, Grünert S, Kirschner J, Eisner V, Horvath R
Human molecular genetics 2018 Apr 1;27(7):1186-1195
Human molecular genetics 2018 Apr 1;27(7):1186-1195
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2.
Zhou L, Li R, Liu C, Sun T, Htet Aung LH, Chen C, Gao J, Zhao Y, Wang K
Free radical biology & medicine 2017 Mar;104:360-370
Free radical biology & medicine 2017 Mar;104:360-370
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):169-176
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):169-176
Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population.
Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, Renard P, Raes M, Arnould T
Journal of cellular physiology 2016 Sep;231(9):1913-31
Journal of cellular physiology 2016 Sep;231(9):1913-31
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B, Zhang J, Li L, Feng D
The EMBO journal 2016 Jul 1;35(13):1368-84
The EMBO journal 2016 Jul 1;35(13):1368-84
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T
The Journal of cell biology 2016 Jan 18;212(2):157-66
The Journal of cell biology 2016 Jan 18;212(2):157-66
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M
Molecular biology of the cell 2016 Jan 15;27(2):349-59
Molecular biology of the cell 2016 Jan 15;27(2):349-59
Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling.
Otera H, Miyata N, Kuge O, Mihara K
The Journal of cell biology 2016 Feb 29;212(5):531-44
The Journal of cell biology 2016 Feb 29;212(5):531-44
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T
The Journal of cell biology 2014 Mar 17;204(6):919-29
The Journal of cell biology 2014 Mar 17;204(6):919-29
Loss of Yme1L perturbates mitochondrial dynamics.
Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z
Cell death & disease 2013 Oct 31;4:e896
Cell death & disease 2013 Oct 31;4:e896
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
Losón OC, Song Z, Chen H, Chan DC
Molecular biology of the cell 2013 Mar;24(5):659-67
Molecular biology of the cell 2013 Mar;24(5):659-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SMCR7,MID49 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SMCR7,MID49. This antibody recognizes human,mouse,rat antigen. The SMCR7,MID49 antibody has been validated for the following applications: ELISA, WB, IHC analysis.