CABT-RM120

antibody from Creative Diagnostics

Targeting: MORC3 KIAA0136, NXP2, ZCW5, ZCWCC3

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-RM120

Provider

Creative Diagnostics

Product name

Mouse Anti-MORC3 monoclonal antibody, clone 28B0

Antibody type

Monoclonal

Description

MORC family CW-type zinc finger protein 3 is encoded by the MORC3 gene in human. MORC3 is a homodimeric protein of the MORC protein family characterized by conserved structures consisting of Gyrase H, Hsp90, and MutL (GHL)-ATPase domain at its N-terminus and a CW type zinc finger domain (aa 404-454). It is expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, and liver. MORC3 serves as a nuclear factor that forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. It is also shown to be a target of herpes simplelx virus 1 (HSV-1) ICP0-mediated degradation. It is shown to be essential for fully efficient recruitment of PML, Sp100, hDaxx, and H2AX to sites associated with HSV-1 genomes entering the host cell nucleus. MORC3 recruits TP53 and SP100 to PML-NBs, hence, it is also involved in the regulation of TP53 activity. It regulates p53 activation via MORC3-ATPase activity. It can also induce p53-dependent premature senescence.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG