Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS61176 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- POLG2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human POLG2.
- Description
- DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol ÎÛ2 (polymerase (DNA directed), gamma 2, accessory subunit), also known as mitochondrial DNA polymerase accessory subunit, POLB, HP55, PEOA4, POLGB, MTPOLB, POLG-BETA or POLG2, is a 485 amino acid subunit of mitochondrial DNA pol ÎÛ. DNA pol ÎÛ2 enhances DNA binding and promotes processive DNA synthesis. Defects in the gene encoding DNA pol ÎÛ2 are the cause of PEOA4 (progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4).
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of POLG2 pAb at 1:500 dilutionLane1:A549 whole cell lysateLane2:Hela whole cell lysateLane3:H9C2 whole cell lysateLane4:SP20 whole cell lysate