BS8363

antibody from Bioworld Technology, Inc

Targeting: POLG2 HP55, MTPOLB

Immunohistochemistry

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Validation data

Product number: BS8363 - Provider product page
Provider: Bioworld Technology, Inc
Product name: POLG2 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human POLG2.
Description: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol ÎÛ2 (polymerase (DNA directed), gamma 2, accessory subunit), also known as mitochondrial DNA polymerase accessory subunit, POLB, HP55, PEOA4, POLGB, MTPOLB, POLG-BETA or POLG2, is a 485 amino acid subunit of mitochondrial DNA pol ÎÛ. DNA pol ÎÛ2 enhances DNA binding and promotes processive DNA synthesis. Defects in the gene encoding DNA pol ÎÛ2 are the cause of PEOA4 (progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4).
Reactivity: Human
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

POLG2 protein structure - BS8363 shown in red.