Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 14635-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14635-1-AP, RRID:AB_2082621
- Product name
- CNPY2, MSAP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CNPY2, MSAP antibody (Cat. #14635-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury.
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.
Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling.
CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
Zhao L, Li H, Gao Q, Xu J, Zhu Y, Zhai M, Zhang P, Shen N, Di Y, Wang J, Chen T, Huang M, Sun J, Liu C
Frontiers in pharmacology 2021;12:609693
Frontiers in pharmacology 2021;12:609693
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
Kakehashi A, Suzuki S, Shiota M, Raymo N, Gi M, Tachibana T, Stefanov V, Wanibuchi H
Cancers 2021 Jul 19;13(14)
Cancers 2021 Jul 19;13(14)
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Liu AM, Chen BL, Yu LT, Liu T, Shi LL, Yu PP, Qu YB, So KF, Zhou LB
Neural regeneration research 2020 Dec;15(12):2306-2317
Neural regeneration research 2020 Dec;15(12):2306-2317
Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury.
Liu C, Liu Y, He J, Mu R, Di Y, Shen N, Liu X, Gao X, Wang J, Chen T, Fang T, Li H, Tian F
Frontiers in pharmacology 2019;10:789
Frontiers in pharmacology 2019;10:789
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.
Cui Y, Wang Y, Liu G
International journal of molecular medicine 2019 May;43(5):2015-2023
International journal of molecular medicine 2019 May;43(5):2015-2023
Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling.
Zhao L, Zhai M, Yang X, Guo H, Cao Y, Wang D, Li P, Liu C
Journal of cellular and molecular medicine 2019 Dec;23(12):8173-8183
Journal of cellular and molecular medicine 2019 Dec;23(12):8173-8183
CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
Hong F, Liu B, Wu BX, Morreall J, Roth B, Davies C, Sun S, Diehl JA, Li Z
Nature structural & molecular biology 2017 Oct;24(10):834-839
Nature structural & molecular biology 2017 Oct;24(10):834-839
Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
Do HT, Bruelle C, Tselykh T, Jalonen P, Korhonen L, Lindholm D
The Journal of biological chemistry 2013 Oct 11;288(41):29613-20
The Journal of biological chemistry 2013 Oct 11;288(41):29613-20
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D
The Journal of biological chemistry 2012 Apr 13;287(16):12602-11
The Journal of biological chemistry 2012 Apr 13;287(16):12602-11
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 14635-1-AP(CNPY2,MSAP antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CNPY2,MSAP (IP:14635-1-AP, 3ug; Detection:14635-1-AP 1:500) with HepG2 cells lysate 600ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 14635-1-AP(CNPY2,MSAP antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CNPY2,MSAP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CNPY2,MSAP. This antibody recognizes human,mouse,rat antigen. The CNPY2,MSAP antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.