Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- PAB3431 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB3431, RRID:AB_1576937
- Product name
- LYN polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of LYN.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.
Lyn kinase is activated following thrombopoietin stimulation of the megakaryocytic cell line B1647.
Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB
The Journal of biological chemistry 2003 Oct 3;278(40):38628-36
The Journal of biological chemistry 2003 Oct 3;278(40):38628-36
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.
Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, Arlinghaus R, Talpaz M
Blood 2003 Jan 15;101(2):690-8
Blood 2003 Jan 15;101(2):690-8
Lyn kinase is activated following thrombopoietin stimulation of the megakaryocytic cell line B1647.
Santini V, Scappini B, Grossi A, Gozzini A, Bonsi L, Pagliai G, Rossi Ferrini P, Bagnara GP
Haematologica 2002 Dec;87(12):1242-7
Haematologica 2002 Dec;87(12):1242-7
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- The LYN polyclonal antibody (Cat # PAB3431) is used in Western blot to detect LYN in mouse liver tissue lysate.
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with LYN polyclonal antibody (Cat # PAB3431) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)