628102

LYN antibody from BioLegend
JTK8
Western blot
Data presented on provider website
Immunocytochemistry
Recommended by provider
Immunoprecipitation
Recommended by provider

Antibody data

Product number
628102
Provider
BioLegend
Proper citation
BioLegend Cat#628102, RRID:AB_2234839
Product name
Purified anti-Lyn
Provider product page
BioLegend - 628102
Antibody type
Monoclonal
Antigen
Partial recombinant Lyn (aa 8-238) expressed in bacteria
Description
Lyn is a tyrosine protein kinase and a member of the src subfamily. Two isoforms of Lyn have been reported: Lyn A, 53 kD and Lyn B, 56 kD. Lyn is predominantly expressed in macrophages, B cells, and platelets. Lyn exhibits both stimulatory activity (mast cells) and inhibitory activity (B cells), and has been shown to increase p53 levels and inhibit nuclear export. Recent reports have suggested that Lyn may participate in the induction of apoptosis by genotoxic agents. Lyn has been shown to be activated in late G1 by stem cell factor and is increased in myeloid leukemias. Lyn interacts with the high affinity IgE receptor, actin cytoskeleton, γ-tubulin, and p53. The LYN-01 monoclonal antibody recognizes the human, mouse, and rat Lyn and has been shown to be useful for Western blotting, immunoprecipitation, and immunocytochemistry.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4 °C.