Ab113790

antibody from Aladdin Scientific Corporation

Targeting: LYN JTK8

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab113790

Provider

Aladdin Scientific Corporation

Product name

Lyn Mouse mAb

Antibody type

Monoclonal

Description

Mouse anti Human Lyn Antibody, Monoclonal (1C8-H3-G6), could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionDown regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 8-238


Antibody clone number

1C8-H3-G6

Vial size

100μl,10μl,1ml,50μl

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.