21537-1-AP

antibody from Proteintech Group

Targeting: RETREG1 FAM134B, FLJ20152, JK1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

21537-1-AP

Provider

Proteintech Group

Product name

FAM134B antibody

Antibody type

Polyclonal

Description

KD/KO validated FAM134B antibody (Cat. #21537-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Nature cell biology 2024 Mar;26(3):378-392

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The p24-family and COPII subunit SEC24C facilitate the clearance of alpha1-antitrypsin Z from the endoplasmic reticulum to lysosomes.

Roberts BS, Mitra D, Abishek S, Beher R, Satpute-Krishnan P
Molecular biology of the cell 2024 Mar 1;35(3):ar45

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USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy.

Zhang M, Wang Z, Zhao Q, Yang Q, Bai J, Yang C, Zhang ZR, Liu Y
Autophagy 2024 Aug;20(8):1780-1797

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Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development.

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Developmental cell 2023 Sep 25;58(18):1733-1747.e6

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Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells.

Li JY, Tian T, Han B, Yang T, Guo YX, Wu JY, Chen YS, Yang Q, Xie RJ
World journal of gastroenterology 2023 Sep 14;29(34):5038-5053

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A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.

Kim DY, Shin JY, Lee JE, Kim HN, Chung SJ, Yoo HS, Kim SJ, Cho HJ, Lee EJ, Nam SJ, Kim SH, Jang J, Lee SE, Lee PH
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 12;120(37):e2221929120

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Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.

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Seneca Valley Virus Degrades STING via PERK and ATF6-Mediated Reticulophagy.

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Viruses 2023 Nov 3;15(11)

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Combinatorial selective ER-phagy remodels the ER during neurogenesis.

Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW
bioRxiv : the preprint server for biology 2023 Nov 10;

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Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.

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Nature 2023 Jun;618(7964):402-410

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Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.

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Nature 2023 Jun;618(7964):394-401

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Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.

Deng H, Chen W, Zhang B, Zhang Y, Han L, Zhang Q, Yao S, Wang H, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793

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Molecular characterization of wild-type and HSAN2B-linked FAM134B.

Kanamori A, Hinaga S, Hirata Y, Amaya F, Oh-Hashi K
Molecular biology reports 2023 Jul;50(7):6005-6017

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Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker.

Shi Y, Zou X, Zheng X, Wu Y, Han J, Han S
Autophagy 2023 Jul;19(7):2015-2025

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Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication.

Williams JM, Chen YJ, Cho WJ, Tai AW, Tsai B
The Journal of cell biology 2023 Jul 3;222(7)

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V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation.

Sun Y, Wang X, Yang X, Wang L, Ding J, Wang CC, Zhang H, Wang X
Developmental cell 2023 Dec 4;58(23):2761-2775.e5

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TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins.

Hayashi Y, Takatori S, Warsame WY, Tomita T, Fujisawa T, Ichijo H
The EMBO journal 2023 Dec 1;42(23):e114272

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Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication.

Tan X, Cai K, Li J, Yuan Z, Chen R, Xiao H, Xu C, Hu B, Qin Y, Ding B
Cell reports 2023 Apr 25;42(4):112286

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CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.

Ishii S, Chino H, Ode KL, Kurikawa Y, Ueda HR, Matsuura A, Mizushima N, Itakura E
Molecular biology of the cell 2023 Apr 1;34(4):ar29

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Sec23a inhibits the self-renewal of melanoma cancer stem cells via inactivation of ER-phagy.

Sun Z, Liu D, Zeng B, Zhao Q, Li X, Chen H, Wang J, Rosie Xing H
Cell communication and signaling : CCS 2022 Mar 2;20(1):22

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Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol.

Guo YX, Han B, Yang T, Chen YS, Yang Y, Li JY, Yang Q, Xie RJ
World journal of gastroenterology 2022 Jun 21;28(23):2569-2581

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The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes.

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Biochimica et biophysica acta. Molecular basis of disease 2022 Jun 1;1868(6):166391

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STING1 is essential for an RNA-virus triggered autophagy.

Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2022 Apr;18(4):816-828

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RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.

Luo R, Liang H, Zhang W, Li G, Zhao K, Hua W, Song Y, Yang C
Acta biochimica et biophysica Sinica 2022 Apr 25;54(4):524-536

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FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.

Luo R, Li S, Li G, Lu S, Zhang W, Liu H, Lei J, Ma L, Ke W, Liao Z, Wang B, Song Y, Wang K, Zhang Y, Yang C
Oxidative medicine and cellular longevity 2021;2021:3843145

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ATF4 links ER stress with reticulophagy in glioblastoma cells.

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Autophagy 2021 Sep;17(9):2432-2448

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Endoplasmic reticulum tubules limit the size of misfolded protein condensates.

Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S
eLife 2021 Sep 1;10

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Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway.

Li L, Zhao S, Liu Z, Zhang N, Pang S, Liu J, Liu C, Fan Y
Cell death & disease 2021 Feb 26;12(2):220

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Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.

Stefely JA, Zhang Y, Freiberger EC, Kwiecien NW, Thomas HE, Davis AM, Lowry ND, Vincent CE, Shishkova E, Clark NA, Medvedovic M, Coon JJ, Pagliarini DJ, Mercer CA
Autophagy 2020 Dec;16(12):2219-2237

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CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy.

Nthiga TM, Kumar Shrestha B, Sjøttem E, Bruun JA, Bowitz Larsen K, Bhujabal Z, Lamark T, Johansen T
The EMBO journal 2020 Aug 3;39(15):e103649

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Intrinsically Disordered Protein TEX264 Mediates ER-phagy.

Chino H, Hatta T, Natsume T, Mizushima N
Molecular cell 2019 Jun 6;74(5):909-921.e6

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.

An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW
Molecular cell 2019 Jun 6;74(5):891-908.e10

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Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells.

Liao Y, Duan B, Zhang Y, Zhang X, Xia B
The Journal of biological chemistry 2019 Dec 27;294(52):20009-20023

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Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B
Molecular cell 2019 Aug 8;75(3):442-456.e4

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Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD.

Schultz ML, Krus KL, Kaushik S, Dang D, Chopra R, Qi L, Shakkottai VG, Cuervo AM, Lieberman AP
Nature communications 2018 Sep 10;9(1):3671

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Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.

Lennemann NJ, Coyne CB
Autophagy 2017 Feb;13(2):322-332