ACOX3

Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

Description

Acyl-CoA oxidase 3, pristanoyl

Tissue specificity

Low tissue specificity

Subcell location

Peroxisomes

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (8366282 - 8440723)

Ensembl ID

ENSG00000087008  (ver. 103.38)

Orthologs

Mouse Acox3: ENSMUSG00000029098

UniProt

O15254

neXtProt

NX_O15254

Human splice variants
Mouse splice variants

Protein structure