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- Product number
- 15073-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15073-1-AP, RRID:AB_2142033
- Product name
- METTL3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated METTL3 antibody (Cat. #15073-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse, Rat, Monkey and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA.
Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.
Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.
Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice.
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.
Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1.
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Vitamin B12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer.
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.
Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library.
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA.
N6-methyladenosine modification of CDH1 mRNA promotes PM2.5-induced pulmonary fibrosis via mediating epithelial mesenchymal transition.
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.
Role of epigenetic m6 A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.
mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity.
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.
MYC promotes cancer progression by modulating m6 A modifications to suppress target gene translation.
RNA m6 A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A).
The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs.
HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.
Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts.
Local translation in nuclear condensate amyloid bodies.
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype.
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Nonsegmented Negative-Sense RNA Viruses Utilize N 6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity.
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
A defined N6-methyladenosine (m(6)A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.
Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.
The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.
m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.
m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation.
N(6)-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.
Validation strategies for antibodies targeting modified ribonucleotides.
METTL3 potentiates resistance to cisplatin through m6 A modification of TFAP2C in seminoma.
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA.
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Dynamic landscape and evolution of m6A methylation in human.
ANKLE1 N6 -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base-specific resolution.
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity.
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism.
m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection.
Epitranscriptomic N6-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification.
Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates.
Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m6A RNA Methylation in the Intestine of Weaning Piglets.
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex.
HIV-1 envelope proteins up-regulate N(6)-methyladenosine levels of cellular RNA independently of viral replication.
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis.
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
m6A modification controls the innate immune response to infection by targeting type I interferons.
m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine.
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
The m6A-methylase complex recruits TREX and regulates mRNA export.
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
The Role of m6A/m-RNA Methylation in Stress Response Regulation.
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.
Dynamic m6A modification regulates local translation of mRNA in axons.
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
m6A Facilitates eIF4F-Independent mRNA Translation.
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine.
Thiol-linked alkylation of RNA to assess expression dynamics.
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
N6-methyladenosine-dependent regulation of messenger RNA stability.
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Kim GW, Siddiqui A
Journal of virology 2022 Feb 23;96(4):e0165521
Journal of virology 2022 Feb 23;96(4):e0165521
Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.
Xie SJ, Lei H, Yang B, Diao LT, Liao JY, He JH, Tao S, Hu YX, Hou YR, Sun YJ, Peng YW, Zhang Q, Xiao ZD
Frontiers in cell and developmental biology 2021;9:744171
Frontiers in cell and developmental biology 2021;9:744171
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.
Li CM, Li M, Zhao WB, Ye ZC, Peng H
Frontiers in molecular biosciences 2021;8:654465
Frontiers in molecular biosciences 2021;8:654465
Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.
Cheng Z, Gao S, Liang X, Lian C, Chen J, Fang C
BioMed research international 2021;2021:1015293
BioMed research international 2021;2021:1015293
Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice.
Su X, Shen Y, Jin Y, Kim IM, Weintraub NL, Tang Y
Frontiers in pharmacology 2021;12:654316
Frontiers in pharmacology 2021;12:654316
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.
Chen C, Yuan W, Zhou Q, Shao B, Guo Y, Wang W, Yang S, Guo Y, Zhao L, Dang Q, Yang X, Wang G, Kang Q, Ji Z, Liu J, Sun Z
Theranostics 2021;11(9):4298-4315
Theranostics 2021;11(9):4298-4315
Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1.
Yang Z, Zhao F, Gu X, Feng L, Xu M, Li T, Liu X, Zhang X
American journal of cancer research 2021;11(4):1428-1445
American journal of cancer research 2021;11(4):1428-1445
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
Tan L, Tang Y, Li H, Li P, Ye Y, Cen J, Gui C, Luo J, Cao J, Wei J
Frontiers in oncology 2021;11:641833
Frontiers in oncology 2021;11:641833
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Fang C, He M, Li D, Xu Q
Cellular signalling 2021 Sep;85:110060
Cellular signalling 2021 Sep;85:110060
Vitamin B12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer.
Xu H, Li X, Wang S, Li F, Gao J, Yan L, Zhu L
Epigenomics 2021 Sep;13(17):1359-1383
Epigenomics 2021 Sep;13(17):1359-1383
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y
Molecular cancer 2021 Sep 8;20(1):114
Molecular cancer 2021 Sep 8;20(1):114
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.
Peng Z, Gong Y, Wang X, He W, Wu L, Zhang L, Xiong L, Huang Y, Su L, Shi P, Cao X, Liu R, Li Y, Xiao H
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Sep 20;
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Sep 20;
Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library.
Zhang Z, Chen T, Chen HX, Xie YY, Chen LQ, Zhao YL, Liu BD, Jin L, Zhang W, Liu C, Ma DZ, Chai GS, Zhang Y, Zhao WS, Ng WH, Chen J, Jia G, Yang J, Luo GZ
Nature methods 2021 Oct;18(10):1213-1222
Nature methods 2021 Oct;18(10):1213-1222
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.
Liu HT, Zou YX, Zhu WJ, Sen-Liu, Zhang GH, Ma RR, Guo XY, Gao P
Cell death and differentiation 2021 Oct 4;
Cell death and differentiation 2021 Oct 4;
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
Zhao K, Yang C, Zhang J, Sun W, Zhou B, Kong X, Shi J
Cell death discovery 2021 Oct 13;7(1):291
Cell death discovery 2021 Oct 13;7(1):291
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
Takemoto S, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2021 Nov;193:114766
Biochemical pharmacology 2021 Nov;193:114766
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X
Cell reports 2021 Nov 9;37(6):109968
Cell reports 2021 Nov 9;37(6):109968
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
N6-methyladenosine modification of CDH1 mRNA promotes PM2.5-induced pulmonary fibrosis via mediating epithelial mesenchymal transition.
Ning J, Du H, Zhang Y, Liu Q, Jiang T, Pang Y, Tian X, Yan L, Niu Y, Zhang R
Toxicological sciences : an official journal of the Society of Toxicology 2021 Nov 4;
Toxicological sciences : an official journal of the Society of Toxicology 2021 Nov 4;
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.
Li X, Xiong W, Long X, Dai X, Peng Y, Xu Y, Zhang Z, Zhang L, Liu Y
Biology of reproduction 2021 Nov 15;105(5):1221-1233
Biology of reproduction 2021 Nov 15;105(5):1221-1233
Role of epigenetic m6 A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Parial R, Li H, Li J, Archacki S, Yang Z, Wang IZ, Chen Q, Xu C, Wang QK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.
Yang R, Lee EE, Kim J, Choi JH, Kolitz E, Chen Y, Crewe C, Salisbury NJH, Scherer PE, Cockerell C, Smith TR, Rosen L, Verlinden L, Galloway DA, Buck CB, Feltkamp MC, Sullivan CS, Wang RC
PLoS pathogens 2021 May;17(5):e1009582
PLoS pathogens 2021 May;17(5):e1009582
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.
Diao LT, Xie SJ, Lei H, Qiu XS, Huang MC, Tao S, Hou YR, Hu YX, Sun YJ, Zhang Q, Xiao ZD
Biochemical and biophysical research communications 2021 May 7;552:52-58
Biochemical and biophysical research communications 2021 May 7;552:52-58
mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J
Molecular cell 2021 May 20;81(10):2064-2075.e8
Molecular cell 2021 May 20;81(10):2064-2075.e8
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Li N, Hui H, Bray B, Gonzalez GM, Zeller M, Anderson KG, Knight R, Smith D, Wang Y, Carlin AF, Rana TM
Cell reports 2021 May 11;35(6):109091
Cell reports 2021 May 11;35(6):109091
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity.
Liu J, Gao M, He J, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J
Nature 2021 Mar;591(7849):322-326
Nature 2021 Mar;591(7849):322-326
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H
Nature 2021 Mar;591(7849):317-321
Nature 2021 Mar;591(7849):317-321
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
Chen S, Kumar S, Espada CE, Tirumuru N, Cahill MP, Hu L, He C, Wu L
PLoS pathogens 2021 Mar;17(3):e1009421
PLoS pathogens 2021 Mar;17(3):e1009421
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352
Clinical and translational medicine 2021 Mar;11(3):e352
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.
Kim GW, Siddiqui A
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.
Wang X, Liu C, Zhang S, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D
Developmental cell 2021 Mar 8;56(5):702-715.e8
Developmental cell 2021 Mar 8;56(5):702-715.e8
MYC promotes cancer progression by modulating m6 A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
RNA m6 A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.
Zheng X, Wang J, Zhang X, Fu Y, Peng Q, Lu J, Wei L, Li Z, Liu C, Wu Y, Yan Q, Ma J
Immunity, inflammation and disease 2021 Jun;9(2):351-362
Immunity, inflammation and disease 2021 Jun;9(2):351-362
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
Jiang D, Hou J, Qian Y, Gao Y, Gao X, Wei S
Biochemical and biophysical research communications 2021 Jun 11;557:85-89
Biochemical and biophysical research communications 2021 Jun 11;557:85-89
Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A).
Lee JH, Hong J, Zhang Z, de la Peña Avalos B, Proietti CJ, Deamicis AR, Guzmán G P, Lam HM, Garcia J, Roudier MP, Sisk AE, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao MK, Zheng S, Johnson-Pais TL, Leach RJ, Elizalde PV, Dray E, Xu K
Science advances 2021 Jul;7(31)
Science advances 2021 Jul;7(31)
The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M
Biochemical pharmacology 2021 Jul;189:114402
Biochemical pharmacology 2021 Jul;189:114402
The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.
Bechara R, Amatya N, Bailey RD, Li Y, Aggor FEY, Li DD, Jawale CV, Coleman BM, Dai N, Gokhale NS, Taylor TC, Horner SM, Poholek AC, Bansal A, Biswas PS, Gaffen SL
Science immunology 2021 Jul 2;6(61)
Science immunology 2021 Jul 2;6(61)
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Mo S, Barin E, Velleca A, Rohwetter TM, Patel DJ, Jaffrey SR, Kharas MG
Cancer cell 2021 Jul 12;39(7):958-972.e8
Cancer cell 2021 Jul 12;39(7):958-972.e8
Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143
RNA biology 2021 Jan;18(1):131-143
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry 2021 Jan-Jun;296:100547
The Journal of biological chemistry 2021 Jan-Jun;296:100547
Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs.
Kim GW, Siddiqui A
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 19;118(3)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 19;118(3)
HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.
Kim GW, Imam H, Khan M, Mir SA, Kim SJ, Yoon SK, Hur W, Siddiqui A
Hepatology (Baltimore, Md.) 2021 Feb;73(2):533-547
Hepatology (Baltimore, Md.) 2021 Feb;73(2):533-547
Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts.
Li T, Zhuang Y, Yang W, Xie Y, Shang W, Su S, Dong X, Wu J, Jiang W, Zhou Y, Li Y, Zhou X, Zhang M, Lu Y, Pan Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21162
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21162
Local translation in nuclear condensate amyloid bodies.
Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.
Gong R, Wang X, Li H, Liu S, Jiang Z, Zhao Y, Yu Y, Han Z, Yu Y, Dong C, Li S, Xu B, Zhang W, Wang N, Li X, Gao X, Yang F, Bamba D, Ma W, Liu Y, Cai B
Pharmacological research 2021 Dec;174:105845
Pharmacological research 2021 Dec;174:105845
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Zhu X, Yang H, Zhang M, Wu X, Jiang L, Liu X, Lv K
Cancer cell international 2021 Dec 4;21(1):645
Cancer cell international 2021 Dec 4;21(1):645
Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
Xue A, Huang Y, Li M, Wei Q, Bu Q
Molecular neurobiology 2021 Aug;58(8):3759-3768
Molecular neurobiology 2021 Aug;58(8):3759-3768
KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
Qi Y, Yao R, Zhang W, Cui Q
Pharmacological research 2021 Aug;170:105713
Pharmacological research 2021 Aug;170:105713
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Zhao S, Lu J, Chen Y, Wang Z, Cao J, Dong Y
Journal of reproductive immunology 2021 Aug;146:103341
Journal of reproductive immunology 2021 Aug;146:103341
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, Yee BA, Li H, Madrigal AA, Neill NJ, Shankar A, Tyagi S, Westbrook TF, Yeo GW
Molecular cell 2021 Aug 5;81(15):3048-3064.e9
Molecular cell 2021 Aug 5;81(15):3048-3064.e9
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Sang W, Xue S, Jiang Y, Lu H, Zhu L, Wang C, Ma J
Life sciences 2021 Aug 1;278:119528
Life sciences 2021 Aug 1;278:119528
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype.
Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R
Nature cell biology 2021 Apr;23(4):355-365
Nature cell biology 2021 Apr;23(4):355-365
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Zong X, Wang H, Xiao X, Zhang Y, Hu Y, Wang F, Wang Y, Lu Z
RNA biology 2021 Apr;18(4):576-586
RNA biology 2021 Apr;18(4):576-586
Nonsegmented Negative-Sense RNA Viruses Utilize N 6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity.
Lu M, Xue M, Wang HT, Kairis EL, Ahmad S, Wei J, Zhang Z, Liu Q, Zhang Y, Gao Y, Garcin D, Peeples ME, Sharma A, Hur S, He C, Li J
Journal of virology 2021 Apr 12;95(9)
Journal of virology 2021 Apr 12;95(9)
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY
Nature communications 2021 Apr 12;12(1):2183
Nature communications 2021 Apr 12;12(1):2183
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Qi B, Yang C, Zhu Z, Chen H
Frontiers in cell and developmental biology 2020;8:574940
Frontiers in cell and developmental biology 2020;8:574940
A defined N6-methyladenosine (m(6)A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.
Gheller BJ, Blum JE, Fong EHH, Malysheva OV, Cosgrove BD, Thalacker-Mercer AE
Cell death discovery 2020;6(1):95
Cell death discovery 2020;6(1):95
Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.
Si W, Li Y, Ye S, Li Z, Liu Y, Kuang W, Chen D, Zhu M
Frontiers in molecular neuroscience 2020;13:103
Frontiers in molecular neuroscience 2020;13:103
The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.
Yuan Y, Du Y, Wang L, Liu X
Journal of Cancer 2020;11(12):3588-3595
Journal of Cancer 2020;11(12):3588-3595
m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.
Zhai J, Li S, Sen S, Opoku-Anane J, Du Y, Chen ZJ, Giudice LC
Frontiers in genetics 2020;11:716
Frontiers in genetics 2020;11:716
m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
He JJ, Li Z, Rong ZX, Gao J, Mu Y, Guan YD, Ren XX, Zi YY, Liu LY, Fan Q, Zhou M, Duan YM, Zhou Q, Deng YZ, Sun LQ
Frontiers in oncology 2020;10:1166
Frontiers in oncology 2020;10:1166
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Xu J, Chen Q, Tian K, Liang R, Chen T, Gong A, Mathy NW, Yu T, Chen X
Oncology reports 2020 Sep;44(3):973-986
Oncology reports 2020 Sep;44(3):973-986
Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation.
Jiang L, Chen T, Xiong L, Xu JH, Gong AY, Dai B, Wu G, Zhu K, Lu E, Mathy NW, Chen XM
Oncology letters 2020 Sep;20(3):2191-2198
Oncology letters 2020 Sep;20(3):2191-2198
N(6)-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.
Kim GW, Imam H, Khan M, Siddiqui A
The Journal of biological chemistry 2020 Sep 11;295(37):13123-13133
The Journal of biological chemistry 2020 Sep 11;295(37):13123-13133
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert FD, Angstman NB, Cardoso MC, König J, Hüttelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R, Meister G
RNA (New York, N.Y.) 2020 Oct;26(10):1489-1506
RNA (New York, N.Y.) 2020 Oct;26(10):1489-1506
METTL3 potentiates resistance to cisplatin through m6 A modification of TFAP2C in seminoma.
Wei J, Yin Y, Zhou J, Chen H, Peng J, Yang J, Tang Y
Journal of cellular and molecular medicine 2020 Oct;24(19):11366-11380
Journal of cellular and molecular medicine 2020 Oct;24(19):11366-11380
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Ho-Xuan H, Glažar P, Latini C, Heizler K, Haase J, Hett R, Anders M, Weichmann F, Bruckmann A, Van den Berg D, Hüttelmaier S, Rajewsky N, Hackl C, Meister G
Nucleic acids research 2020 Oct 9;48(18):10368-10382
Nucleic acids research 2020 Oct 9;48(18):10368-10382
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH
Genes & development 2020 Oct 1;34(19-20):1373-1391
Genes & development 2020 Oct 1;34(19-20):1373-1391
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA.
Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331
Nature cell biology 2020 Nov;22(11):1319-1331
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
Liu X, Qin J, Gao T, Li C, Chen X, Zeng K, Xu M, He B, Pan B, Xu X, Pan Y, Sun H, Xu T, Wang S
Aging 2020 Nov 6;12(21):21638-21659
Aging 2020 Nov 6;12(21):21638-21659
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang YG, Liu GH, Zhang W, Ci W, Qu J
Nucleic acids research 2020 Nov 4;48(19):11083-11096
Nucleic acids research 2020 Nov 4;48(19):11083-11096
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;
bioRxiv : the preprint server for biology 2020 Nov 16;
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
Dynamic landscape and evolution of m6A methylation in human.
Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, Zhang R
Nucleic acids research 2020 Jun 19;48(11):6251-6264
Nucleic acids research 2020 Jun 19;48(11):6251-6264
ANKLE1 N6 -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293
International journal of cancer 2020 Jun 15;146(12):3281-3293
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base-specific resolution.
Lorenz DA, Sathe S, Einstein JM, Yeo GW
RNA (New York, N.Y.) 2020 Jan;26(1):19-28
RNA (New York, N.Y.) 2020 Jan;26(1):19-28
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.
Imam H, Kim GW, Mir SA, Khan M, Siddiqui A
PLoS pathogens 2020 Feb;16(2):e1008338
PLoS pathogens 2020 Feb;16(2):e1008338
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Li D, Cai L, Meng R, Feng Z, Xu Q
International journal of molecular sciences 2020 Feb 28;21(5)
International journal of molecular sciences 2020 Feb 28;21(5)
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity.
Wang L, Song C, Wang N, Li S, Liu Q, Sun Z, Wang K, Yu SC, Yang Q
Nature chemical biology 2020 Dec;16(12):1394-1402
Nature chemical biology 2020 Dec;16(12):1394-1402
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism.
Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604
m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Wang Y, Sun J, Lin Z, Zhang W, Wang S, Wang W, Wang Q, Ning G
Diabetes 2020 Aug;69(8):1708-1722
Diabetes 2020 Aug;69(8):1708-1722
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647
Science advances 2020 Aug;6(34):eaba0647
Epitranscriptomic N6-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.
Choi H, Baek S, Cho B, Kim S, Kim J, Chang Y, Shin J, Kim J
ACS chemical biology 2020 Aug 21;15(8):2087-2097
ACS chemical biology 2020 Aug 21;15(8):2087-2097
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Lu M, Zhang Z, Xue M, Zhao BS, Harder O, Li A, Liang X, Gao TZ, Xu Y, Zhou J, Feng Z, Niewiesk S, Peeples ME, He C, Li J
Nature microbiology 2020 Apr;5(4):584-598
Nature microbiology 2020 Apr;5(4):584-598
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates.
Liu XM, Zhou J, Mao Y, Ji Q, Qian SB
Nature chemical biology 2019 Sep;15(9):865-871
Nature chemical biology 2019 Sep;15(9):865-871
Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
Xue M, Zhao BS, Zhang Z, Lu M, Harder O, Chen P, Lu Z, Li A, Ma Y, Xu Y, Liang X, Zhou J, Niewiesk S, Peeples ME, He C, Li J
Nature communications 2019 Oct 9;10(1):4595
Nature communications 2019 Oct 9;10(1):4595
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Ż, Pan JN, He C, Parisien M, Pan T
Molecular cell 2019 Oct 3;76(1):70-81.e9
Molecular cell 2019 Oct 3;76(1):70-81.e9
Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m6A RNA Methylation in the Intestine of Weaning Piglets.
Gan Z, Wei W, Wu J, Zhao Y, Zhang L, Wang T, Zhong X
ACS omega 2019 Oct 22;4(17):17438-17446
ACS omega 2019 Oct 22;4(17):17438-17446
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex.
Park OH, Ha H, Lee Y, Boo SH, Kwon DH, Song HK, Kim YK
Molecular cell 2019 May 2;74(3):494-507.e8
Molecular cell 2019 May 2;74(3):494-507.e8
HIV-1 envelope proteins up-regulate N(6)-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry 2019 Mar 1;294(9):3249-3260
The Journal of biological chemistry 2019 Mar 1;294(9):3249-3260
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis.
Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772
Oncogene 2019 Jun;38(24):4755-4772
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY
Nature communications 2019 Jun 25;10(1):2782
Nature communications 2019 Jun 25;10(1):2782
Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.
Tian C, Huang Y, Li Q, Feng Z, Xu Q
International journal of molecular sciences 2019 Jan 28;20(3)
International journal of molecular sciences 2019 Jan 28;20(3)
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
Zong X, Zhao J, Wang H, Lu Z, Wang F, Du H, Wang Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Jan 15;202(2):567-578
Journal of immunology (Baltimore, Md. : 1950) 2019 Jan 15;202(2):567-578
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374
Nucleic acids research 2019 Jan 10;47(1):362-374
m6A modification controls the innate immune response to infection by targeting type I interferons.
Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK, Trilling M, Mandelboim M, Hanna JH, Schwartz S, Stern-Ginossar N
Nature immunology 2019 Feb;20(2):173-182
Nature immunology 2019 Feb;20(2):173-182
m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.
Zhang Y, Gu X, Li D, Cai L, Xu Q
International journal of molecular sciences 2019 Dec 27;21(1)
International journal of molecular sciences 2019 Dec 27;21(1)
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
Green NH, Galvan DL, Badal SS, Chang BH, LeBleu VS, Long J, Jonasch E, Danesh FR
Oncogene 2019 Aug;38(34):6211-6225
Oncogene 2019 Aug;38(34):6211-6225
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, Zhang M, Hong H, Yao S, Zhao Y, Zhang Z
Autophagy 2019 Aug;15(8):1419-1437
Autophagy 2019 Aug;15(8):1419-1437
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine.
Miao W, Li L, Zhao Y, Dai X, Chen X, Wang Y
Nature communications 2019 Aug 9;10(1):3613
Nature communications 2019 Aug 9;10(1):3613
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG
Cell reports 2019 Aug 13;28(7):1703-1716.e6
Cell reports 2019 Aug 13;28(7):1703-1716.e6
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Chen J, Zhang YC, Huang C, Shen H, Sun B, Cheng X, Zhang YJ, Yang YG, Shu Q, Yang Y, Li X
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications 2019 Apr 23;10(1):1898
Nature communications 2019 Apr 23;10(1):1898
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI
Nature 2018 Sep;561(7724):556-560
Nature 2018 Sep;561(7724):556-560
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, Tienda SM, Chryplewicz A, Zhu AC, Yang Y, Huang JT, Chen SM, Xu ZG, Leng XH, Yu XC, Cao J, Zhang Z, Liu J, Lengyel E, He C
Nature cell biology 2018 Sep;20(9):1074-1083
Nature cell biology 2018 Sep;20(9):1074-1083
The m6A-methylase complex recruits TREX and regulates mRNA export.
Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I, Wilson SA
Scientific reports 2018 Sep 14;8(1):13827
Scientific reports 2018 Sep 14;8(1):13827
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research 2018 Nov;28(11):1062-1076
Cell research 2018 Nov;28(11):1062-1076
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Hua W, Zhao Y, Jin X, Yu D, He J, Xie D, Duan P
Gynecologic oncology 2018 Nov;151(2):356-365
Gynecologic oncology 2018 Nov;151(2):356-365
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, Jiang Y, Ye L, Chen Q, Zhou X, Lin S, Yuan Q
Nature communications 2018 Nov 14;9(1):4772
Nature communications 2018 Nov 14;9(1):4772
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V
Cell reports 2018 Nov 13;25(7):1816-1828.e4
Cell reports 2018 Nov 13;25(7):1816-1828.e4
METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.
Feng Z, Li Q, Meng R, Yi B, Xu Q
Journal of cellular and molecular medicine 2018 May;22(5):2558-2568
Journal of cellular and molecular medicine 2018 May;22(5):2558-2568
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, Biggiogera M, Helm M, Soller M, Bühler M, Roignant JY
Genes & development 2018 Mar 1;32(5-6):415-429
Genes & development 2018 Mar 1;32(5-6):415-429
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X, Yu J
Nucleic acids research 2018 Jun 1;46(10):5195-5208
Nucleic acids research 2018 Jun 1;46(10):5195-5208
The Role of m6A/m-RNA Methylation in Stress Response Regulation.
Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, Jakovcevski M, Hanna JH, Leshkowitz D, Uhr M, Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A
Neuron 2018 Jul 25;99(2):389-403.e9
Neuron 2018 Jul 25;99(2):389-403.e9
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.
Taketo K, Konno M, Asai A, Koseki J, Toratani M, Satoh T, Doki Y, Mori M, Ishii H, Ogawa K
International journal of oncology 2018 Feb;52(2):621-629
International journal of oncology 2018 Feb;52(2):621-629
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.
Xia H, Zhong C, Wu X, Chen J, Tao B, Xia X, Shi M, Zhu Z, Trudeau VL, Hu W
Genetics 2018 Feb;208(2):729-743
Genetics 2018 Feb;208(2):729-743
Dynamic m6A modification regulates local translation of mRNA in axons.
Yu J, Chen M, Huang H, Zhu J, Song H, Zhu J, Park J, Ji SJ
Nucleic acids research 2018 Feb 16;46(3):1412-1423
Nucleic acids research 2018 Feb 16;46(3):1412-1423
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell 2018 Feb 15;69(4):636-647.e7
Molecular cell 2018 Feb 15;69(4):636-647.e7
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y
Open biology 2017 Sep;7(9)
Open biology 2017 Sep;7(9)
Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
Chang M, Lv H, Zhang W, Ma C, He X, Zhao S, Zhang ZW, Zeng YX, Song S, Niu Y, Tong WM
Open biology 2017 Sep;7(9)
Open biology 2017 Sep;7(9)
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.
Li Q, Li X, Tang H, Jiang B, Dou Y, Gorospe M, Wang W
Journal of cellular biochemistry 2017 Sep;118(9):2587-2598
Journal of cellular biochemistry 2017 Sep;118(9):2587-2598
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG
Nature medicine 2017 Nov;23(11):1369-1376
Nature medicine 2017 Nov;23(11):1369-1376
m6A Facilitates eIF4F-Independent mRNA Translation.
Coots RA, Liu XM, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB
Molecular cell 2017 Nov 2;68(3):504-514.e7
Molecular cell 2017 Nov 2;68(3):504-514.e7
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, He C, Shi Y
Cell reports 2017 Mar 14;18(11):2622-2634
Cell reports 2017 Mar 14;18(11):2622-2634
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
Liu N, Zhou KI, Parisien M, Dai Q, Diatchenko L, Pan T
Nucleic acids research 2017 Jun 2;45(10):6051-6063
Nucleic acids research 2017 Jun 2;45(10):6051-6063
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.
Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A, Bühler M
Nature structural & molecular biology 2017 Jul;24(7):561-569
Nature structural & molecular biology 2017 Jul;24(7):561-569
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine.
Wu W, Feng J, Jiang D, Zhou X, Jiang Q, Cai M, Wang X, Shan T, Wang Y
Scientific reports 2017 Feb 8;7:41606
Scientific reports 2017 Feb 8;7:41606
Thiol-linked alkylation of RNA to assess expression dynamics.
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Nature methods 2017 Dec;14(12):1198-1204
Nature methods 2017 Dec;14(12):1198-1204
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.
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Cell 2017 Apr 6;169(2):326-337.e12
Cell 2017 Apr 6;169(2):326-337.e12
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell 2016 May 5;62(3):335-345
Molecular cell 2016 May 5;62(3):335-345
N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.
Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L
eLife 2016 Jul 2;5
eLife 2016 Jul 2;5
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
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Cell stem cell 2015 Mar 5;16(3):289-301
Cell stem cell 2015 Mar 5;16(3):289-301
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
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Science (New York, N.Y.) 2015 Feb 27;347(6225):1002-6
Science (New York, N.Y.) 2015 Feb 27;347(6225):1002-6
N6-methyladenosine-dependent regulation of messenger RNA stability.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C
Nature 2014 Jan 2;505(7481):117-20
Nature 2014 Jan 2;505(7481):117-20
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C
Nature chemical biology 2014 Feb;10(2):93-5
Nature chemical biology 2014 Feb;10(2):93-5
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, Wang X, Huang CM, Fu Y, Ge XM, Song SH, Jeong HS, Yanagisawa H, Niu Y, Jia GF, Wu W, Tong WM, Okamoto A, He C, Rendtlew Danielsen JM, Wang XJ, Yang YG
Cell research 2014 Dec;24(12):1403-19
Cell research 2014 Dec;24(12):1403-19
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.
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Cell stem cell 2014 Dec 4;15(6):707-19
Cell stem cell 2014 Dec 4;15(6):707-19
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H
Cell 2013 Nov 7;155(4):793-806
Cell 2013 Nov 7;155(4):793-806
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 15073-1-AP(METTL3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The METTL3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human METTL3. This antibody recognizes human,mouse,rat antigen. The METTL3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
