Ab091154

antibody from Aladdin Scientific Corporation

Targeting: TUBB3 beta-4, CFEOM3, CFEOM3A, FEOM3

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab091154

Provider

Aladdin Scientific Corporation

Product name

Recombinant beta III Tubulin Antibody

Antibody type

Recombinant

Description

Rabbit anti Human Beta III Tubulin Antibody, Recombinant (RR607), could be used for WB, Flow and so on.Application:WB: 1/2000 - 1/5000 Flow: 1/200 - 1/1000Protein FunctionTubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.Post-translationalSome glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antibody clone number

RR607

Vial size

100μl,10μl,1ml,50μl

Concentration

0,088 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.