Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 23995-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- FNDC5 antibody
- Antibody type
- Polyclonal
- Description
- FNDC5 antibody (Cat. #23995-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.
Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.
Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.
Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver.
Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis.
Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53.
Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM.
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance.
The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes.
Effects of myostatin deficiency on PGC-1α and FNDC5 expression in three different murine muscle types.
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.
Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.
Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat.
Li Y, Sun X, Bai Y, Ji Y, Ren H, Yu X, Yan Y, He X, Dong Y, Zhang L, Luo X, Wang H
Aging 2021 Oct 5;13(19):22985-23003
Aging 2021 Oct 5;13(19):22985-23003
Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.
Bretland KA, Lin L, Bretland KM, Smith MA, Fleming SM, Dengler-Crish CM
Neuropathology and applied neurobiology 2021 Dec;47(7):967-978
Neuropathology and applied neurobiology 2021 Dec;47(7):967-978
Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.
He W, Wang P, Chen Q, Li C
Skeletal muscle 2020 Sep 15;10(1):25
Skeletal muscle 2020 Sep 15;10(1):25
Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver.
Canivet CM, Bonnafous S, Rousseau D, Leclere PS, Lacas-Gervais S, Patouraux S, Sans A, Luci C, Bailly-Maitre B, Iannelli A, Tran A, Anty R, Gual P
Biochimica et biophysica acta. Molecular basis of disease 2020 May 1;1866(5):165705
Biochimica et biophysica acta. Molecular basis of disease 2020 May 1;1866(5):165705
Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis.
Ren Y, Zhang J, Wang M, Bi J, Wang T, Qiu M, Lv Y, Wu Z, Wu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110101
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110101
Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53.
Liu Y, Fu Y, Liu Z, Shu S, Wang Y, Cai J, Tang C, Dong Z
Biochimica et biophysica acta. Molecular basis of disease 2020 Jul 1;1866(7):165792
Biochimica et biophysica acta. Molecular basis of disease 2020 Jul 1;1866(7):165792
Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM.
Lang X, Zhao N, He Q, Li X, Li X, Sun C, Zhang X
Brain research bulletin 2020 Dec;165:30-39
Brain research bulletin 2020 Dec;165:30-39
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance.
Shen S, Liao Q, Zhang T, Pan R, Lin L
British journal of pharmacology 2019 Oct;176(20):3983-4001
British journal of pharmacology 2019 Oct;176(20):3983-4001
The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes.
Guo Q, Wei X, Hu H, Yang D, Zhang B, Fan X, Liu J, He H, Oh Y, Wu Q, Zhang Y, Wang C, Liu C, Gu N
Biochemical and biophysical research communications 2019 Dec 10;520(3):619-626
Biochemical and biophysical research communications 2019 Dec 10;520(3):619-626
Effects of myostatin deficiency on PGC-1α and FNDC5 expression in three different murine muscle types.
Bai Y, Bi H, Li L, Li J, Yu X, Ren H, Li Y, Ji Y, Li H, Wang H
Acta histochemica 2019 Apr;121(3):323-329
Acta histochemica 2019 Apr;121(3):323-329
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.
Belviranlı M, Okudan N
Neuromolecular medicine 2018 Sep;20(3):386-400
Neuromolecular medicine 2018 Sep;20(3):386-400
Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.
Noda Y, Kuzuya A, Tanigawa K, Araki M, Kawai R, Ma B, Sasakura Y, Maesako M, Tashiro Y, Miyamoto M, Uemura K, Okuno Y, Kinoshita A
Molecular brain 2018 Oct 24;11(1):61
Molecular brain 2018 Oct 24;11(1):61
Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat.
Fu J, Han Y, Wang J, Liu Y, Zheng S, Zhou L, Jose PA, Zeng C
Journal of the American Heart Association 2016 Oct 26;5(11)
Journal of the American Heart Association 2016 Oct 26;5(11)
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The FNDC5 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FNDC5. This antibody recognizes human, mouse antigen. The FNDC5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.