879

antibody from YO Proteins AB

Targeting: ITGB3 CD61, GP3A, GPIIIa

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

879

Provider

YO Proteins AB

Proper citation

YO Proteins Cat#879, RRID:AB_2128756

Product name

Mouse anti-human CD61 (ß-integrin, Platelet GPIIIa, VNR ß-chain 3) monoclonal antibody, clone CRC54

Antibody type

Monoclonal

Description

Monoclonal antibody anti-human CD61 (ß-integrin, Platelet GPIIIa, VNR ß-chain 3) (IgG1 kappa, clone CRC54). Reacts with platelet glycoprotein gpIIIa/VNR ß chain. This glycoprotein is the common ß chain (ß3 Integrin) of the cytoadhesins, gpIIbIIIa and VNR. Reacts with platelets and megakaryocytes. The antibody reacts preferentially with the activated/occupied form of platelet GPIIb-IIIa (ligand-induced binding site or LIBS epitope) and dissociated form of GPIIIa. CRC54-epitope is located within the N-terminal region of GPIIIa (first 100 aminoacids). CRC54 does not react with platelets of patients with Glanzmann thrombastenia

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

1 ml

References

Submitted references

The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.

Alghisi GC, Ponsonnet L, Rüegg C
PloS one 2009;4(2):e4449

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Effects of platelet glycoprotein IIb-IIIa number and glycoprotein IIIa Leu33Pro polymorphism on platelet aggregation and sensitivity to glycoprotein IIb-IIIa antagonists.

Sirotkina OV, Khaspekova SG, Zabotina AM, Shimanova YV, Mazurov AV
Platelets 2007 Nov;18(7):506-14

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Detection of an epitope specific for the dissociated form of glycoprotein IIIa of platelet membrane glycoprotein IIb-IIIa complex and its expression on the surface of adherent platelets.

Khaspekova SG, Vlasik TN, Byzova TV, Vinogradov DV, Berndt MC, Mazurov AV
British journal of haematology 1993 Oct;85(2):332-40