304402

antibody from BioLegend

Targeting: ITGB3 CD61, GP3A, GPIIIa

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

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Validation data

Product number: 304402 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#304402, RRID:AB_314438
Product name: Purified anti-human CD51/61
Antibody type: Monoclonal
Antigen: CD51/61
Description: CD51/CD61 is an integrin complex known as αVβ3. It is expressed at high levels on osteoclasts, endothelial cells, and melanoma cells and at low levels on platelets and macrophages. CD51 is a heterodimer composed of disulfide-linked 125 kD and 24 kD proteins. CD61 is also a member of the integrin family known as gpIIIa or β3 integrin. It is a 110 kD common β subunit of CD51/CD61 or CD41/CD61 complex. CD51/CD61, also known as the vitronectin receptor, mediates the binding of platelets to immobilized vitronectin without prior activation. Other ligands include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin and the neural adhesion molecule L1. CD51/CD61 also mediates cell-cell adhesion via interaction with CD31. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. The 23C6 antibody has been reported to be useful for blocking studies.
Reactivity: Human, Chicken/Avian, Rabbit
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C.

ITGB3 protein structure - 304402 shown in red.