304413

antibody from BioLegend
Targeting: ITGB3 CD61, GP3A, GPIIIa
Provider product page for 304413
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry
Flow cytometry
Blocking/Neutralizing

Antibody data

Product number
304413 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#304413, RRID:AB_2129617
Product name
LEAF™ Purified anti-human CD51/61 [23C6]
Antibody type
Monoclonal
Antigen
CD51/61
Description
CD51/CD61 is an integrin complex known as αVβ3. It is expressed at high levels on osteoclasts, endothelial cells, and melanoma cells and at low levels on platelets and macrophages. CD51 is a heterodimer composed of disulfide-linked 125 kD and 24 kD proteins. CD61 is also a member of the integrin family known as gpIIIa or β3 integrin. It is a 110 kD common β subunit of CD51/CD61 or CD41/CD61 complex. CD51/CD61, also known as the vitronectin receptor, mediates the binding of platelets to immobilized vitronectin without prior activation. Other ligands include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin and the neural adhesion molecule L1. CD51/CD61 also mediates cell-cell adhesion via interaction with CD31. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. The 23C6 antibody has been reported to be useful for blocking studies.
Reactivity
Human, Chicken/Avian, Rabbit
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 µg
Concentration
1 mg/ml
Storage
The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
ITGB3 protein structure - 304413 shown in red.