MMS22L

The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

Description

MMS22 like, DNA repair protein

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (97142161 - 97283217)

Ensembl ID

ENSG00000146263  (ver. 103.38)

Orthologs

Mouse Mms22l: ENSMUSG00000045751

UniProt

Q6ZRQ5

neXtProt

NX_Q6ZRQ5

Human splice variants
Mouse splice variants

Protein structure