Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS8060 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- INSIG2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human INSIG2.
- Description
- INSIG-1 and INSIG-2 play distinct roles in a negative-feedback mechanism for cholesterol synthesis. INSIG-1 localizes to the endoplasmic reticulum (ER) and binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Sterol induces INSIG-1 binding to SCAP. INSIG-2, another ER protein, binds SCAP in a sterol-regulated manner. Thus, INSIG-1 and INSIG-2 block the export of SCAP from the ER and ultimately inhibit cholesterol synthesis by preventing the proteolytic processing of SREBPs by Golgi enzymes. The critical role of INSIG-1 and INSIG-2 in cholesterol metabolism may be exploited as a therapeutic effect for hypercholesterolemia.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
No validations: Submit validation data