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antibody from Novus Biologicals
Targeting: ATP6AP2
APT6M8-9, ATP6IP2, ATP6M8-9, M8-9, PRR, RENR
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [7]
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- Validations
- Western blot [3]
- Immunohistochemistry [7]
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- Product number
- NBP1-90820 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-90820, RRID:AB_11033498
- Product name
- Rabbit Polyclonal Renin R Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human Renin R antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Renal medullary cyclooxygenase-2 and (pro)renin receptor expression during angiotensin II-dependent hypertension.
Angiotensin II increases the expression of (pro)renin receptor during low-salt conditions.
Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.
The (pro)renin receptor mediates constitutive PLZF-independent pro-proliferative effects which are inhibited by bafilomycin but not genistein.
Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses.
Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.
Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats.
Gonzalez AA, Green T, Luffman C, Bourgeois CR, Gabriel Navar L, Prieto MC
American journal of physiology. Renal physiology 2014 Oct 15;307(8):F962-70
American journal of physiology. Renal physiology 2014 Oct 15;307(8):F962-70
Angiotensin II increases the expression of (pro)renin receptor during low-salt conditions.
Gonzalez AA, Womack JP, Liu L, Seth DM, Prieto MC
The American journal of the medical sciences 2014 Nov;348(5):416-22
The American journal of the medical sciences 2014 Nov;348(5):416-22
Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.
Rosendahl A, Niemann G, Lange S, Ahadzadeh E, Krebs C, Contrepas A, van Goor H, Wiech T, Bader M, Schwake M, Peters J, Stahl R, Nguyen G, Wenzel UO
Laboratory investigation; a journal of technical methods and pathology 2014 Aug;94(8):863-72
Laboratory investigation; a journal of technical methods and pathology 2014 Aug;94(8):863-72
The (pro)renin receptor mediates constitutive PLZF-independent pro-proliferative effects which are inhibited by bafilomycin but not genistein.
Kirsch S, Schrezenmeier E, Klare S, Zaade D, Seidel K, Schmitz J, Bernhard S, Lauer D, Slack M, Goldin-Lang P, Unger T, Zollmann FS, Funke-Kaiser H
International journal of molecular medicine 2014 Apr;33(4):795-808
International journal of molecular medicine 2014 Apr;33(4):795-808
Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses.
Zaade D, Schmitz J, Benke E, Klare S, Seidel K, Kirsch S, Goldin-Lang P, Zollmann FS, Unger T, Funke-Kaiser H
PloS one 2013;8(3):e57674
PloS one 2013;8(3):e57674
Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.
Prieto MC, Williams DE, Liu L, Kavanagh KL, Mullins JJ, Mitchell KD
American journal of physiology. Renal physiology 2011 Feb;300(2):F581-8
American journal of physiology. Renal physiology 2011 Feb;300(2):F581-8
Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats.
Gonzalez AA, Lara LS, Luffman C, Seth DM, Prieto MC
Hypertension (Dallas, Tex. : 1979) 2011 Apr;57(4):859-64
Hypertension (Dallas, Tex. : 1979) 2011 Apr;57(4):859-64
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Renin R Antibody [NBP1-90820] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Renin R Antibody [NBP1-90820] - Analysis in HEK293 cells transfected with control siRNA, target specific siRNA probe #1 and #2. Remaining relative intensity is presented. Loading control: Anti-PPIB.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Renin R Antibody [NBP1-90820] - Analysis in control (vector only transfected HEK293T lysate) and ATP6AP2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human placenta shows moderate cytoplasmic/ membranous positivity in trophoblastic cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human renal cancer shows moderate membranous positivity in tumor cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human cerebral cortex shows moderate cytoplasmic/ membranous positivity in neurons and moderately stained neuropil.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human pancreas shows moderate cytoplasmic positivity in islets of Langerhans.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human cerebellum shows moderate cytoplasmic/ membranous positivity in cells in granular layer
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human pancreas shows moderate cytoplasmic positivity in islets of Langerhans.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Renin R Antibody [NBP1-90820] - Staining of human pancreas shows moderate cytoplasmic positivity in islets of Langerhans.
