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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Immunohistochemistry [1]
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- Product number
- AF2667 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Biglycan Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human Biglycan in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P21810- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Intimal hyperplasia induced by vascular intervention causes lipoprotein retention and accelerated atherosclerosis.
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases.
Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy.
Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.
Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium.
Kijani S, Vázquez AM, Levin M, Borén J, Fogelstrand P
Physiological reports 2017 Jul;5(14)
Physiological reports 2017 Jul;5(14)
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
Melchior JT, Sawyer JK, Kelley KL, Shah R, Wilson MD, Hantgan RR, Rudel LL
Journal of lipid research 2013 Sep;54(9):2495-503
Journal of lipid research 2013 Sep;54(9):2495-503
Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases.
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad GW
Investigative ophthalmology & visual science 2013 Feb 5;54(2):1014-25
Investigative ophthalmology & visual science 2013 Feb 5;54(2):1014-25
Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy.
Thompson J, Wilson P, Brandewie K, Taneja D, Schaefer L, Mitchell B, Tannock LR
The American journal of pathology 2011 Sep;179(3):1179-87
The American journal of pathology 2011 Sep;179(3):1179-87
Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.
Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R
The Journal of pathology 2009 May;218(1):131-42
The Journal of pathology 2009 May;218(1):131-42
Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium.
Kitaya K, Yasuo T
Journal of leukocyte biology 2009 Mar;85(3):391-400
Journal of leukocyte biology 2009 Mar;85(3):391-400
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Biglycan in Human Kidney Array. Biglycan was detected in immersion fixed paraffin-embedded sections of human kidney array using Human Biglycan Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2667) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
