BS6639

antibody from Bioworld Technology, Inc
Targeting: IDO1 IDO, INDO
Provider product page for BS6639
Western blot
Immunohistochemistry

Antibody data

Product number
BS6639 - Provider product page
Provider
Bioworld Technology, Inc
Product name
INDO polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human INDO.
Description
Indoleamine 2,3-dioxygenase (IDO) is an IFN-ÎÛ inducible enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. The gene encoding human IDO maps to chromosome 8p12-p11. IDO, also known as INDO, is an important modulator of immunological responses and protects allogeneic concepti from alloreactive maternal lymphocytes. IDO mediates an interesting inhibitory effect of HeLa cells co-cultured with human PBLs. The ILN-2-induced proliferation response of PBLs is diminished in the presence of HeLa cells while an IDO inhbitor negates this effect. Flow cytometric analysis indicates both mature and immature CD123-positive dentritic cells suppress T cell activity using IDO. IDO-transfected cells co-cultured with T cells reduces T cell proliferation.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IDO1 protein structure - BS6639 shown in red.