AF1517

antibody from Novus Biologicals

Targeting: ULBP3 RAET1N

Western blot (Data presented on provider website)

Blocking/Neutralizing (Data presented on provider website)

Antibody Data

Product number

AF1517

Provider

Novus Biologicals

Product name

Goat Polyclonal ULBP-3 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects human ULBP-3 in direct ELISAs and Western blots. In these formats, approximately 5% cross-reactivity with recombinant human (rh) ULBP-2 is observed and less than 1% cross-reactivity with rhULBP-1 is observed.

Reactivity

Human

Host

Goat

Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma.

Weil S, Memmer S, Lechner A, Huppert V, Giannattasio A, Becker T, Müller-Runte A, Lampe K, Beutner D, Quaas A, Schubert R, Herrmann E, Steinle A, Koehl U, Walter L, von Bergwelt-Baildon MS, Koch J
Frontiers in immunology 2017;8:387

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Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus.

Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K
PLoS pathogens 2016 Aug;12(8):e1005868

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Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids.

Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer EH, Cerwenka A, Steinle A, Koehl U, Koch J
BMC cancer 2015 May 3;15:351

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Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms.

Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015 Mar;63(3):217-27

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The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells.

Fernández-Messina L, Ashiru O, Agüera-González S, Reyburn HT, Valés-Gómez M
Journal of cell science 2011 Feb 1;124(Pt 3):321-7

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NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting.

McGilvray RW, Eagle RA, Watson NF, Al-Attar A, Ball G, Jafferji I, Trowsdale J, Durrant LG
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6993-7002