Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS60567 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CAPNS2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human CAPNS2
- Description
- The Calpain family of proteins are calcium-regulated thiol proteases which have broad endopeptidase activity throughout the body. Calpain small subunit 2, also known as CSS2 or CAPNS2, is a calcium-dependent protease that is expressed ubiquitously in the cytoplasm. Part of a heterodimer composed of a small subunit and a large subunit, CSS2 catalyzes proteolysis of various proteins involved in cytoskeletal remodeling and signal transduction. CSS2 also acts as a chaperone to the larger subunit, mediating its correct folding and conformation. When bound as a heterodimer, CSS2 is thought to keep the catalytic activity of the large subunit dormant. After binding calcium, CSS2 is released from the complex, thereby activating the large subunit and allowing CSS2 to translocate from the cytoplasm to the cell membrane. Defects in the gene encoding CSS2 result in incorrect calpain activity and retarded fetal development, suggesting that CSS2 expression is essential for proper growth.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of CAPNS2 pAb at 1:500 dilutionLane1:Hela whole cell lysateLane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate