CABT-RM126

antibody from Creative Diagnostics

Targeting: BCAP31 6C6-Ag, BAP31, CDM, DXS1357E

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-RM126

Provider

Creative Diagnostics

Product name

Mouse Anti-BCAP31 monoclonal antibody, clone 255-B9

Antibody type

Monoclonal

Description

B-cell receptor-associated protein 31 is encoded by the BCAP31 gene in human. BAP31 is an endoplasmic reticulum (ER) membrane protein that is also expressed on surface (csBAP31) of embryonic stem cells. ER associated BAP1 palsy a significant role as a molecular chaperone for the newly synthesized transmembrane proteins and also acts as an important regulator of apoptosis. It interacts with pro-caspase-8L and Bcl-2/Bcl-xL on the ER membrane and is cleaved by caspase-8. The resulting cleaved product, p20, is an important inducer of apoptosis. The cell surface expressed BAP31 is shown to promote cell survival through the regulation of cell adhesion to the extracellular matrix in human embryonic stem cells. csBAP31 is also suggested to be a putative pro-apoptotic flag on cancer cells. Its expression is shown to be enhanced in caspase3/7 high A549 cells and csBAP31-positive cells display diminished survival capacity. Higher levels of csBAP31 are reported to contribute to poor survival cancer cells.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG