Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Western blot [1]
- Flow cytometry [1]
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Validation data
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- Product number
- ABIN1881358 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-GRB2-Associated Binding Protein 2 (GAB2) (N-Term), (AA 3-30) antibody
- Antibody type
- Polyclonal
- Antigen
- This GAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2.
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- N-Term,AA 3-30
- Antibody clone number
- RB21209
- Vial size
- 400 μL
- Concentration
- 0.5 mg/mL
Submitted references In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.
Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
Dunn GP, Cheung HW, Agarwalla PK, Thomas S, Zektser Y, Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L, Getz G, Liu JF, Hirsch M, Vazquez F, Root DE, Beroukhim R, Drapkin R, Hahn WC
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 21;111(3):1102-7
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 21;111(3):1102-7
Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T
The Journal of biological chemistry 2001 Nov 30;276(48):45175-83
The Journal of biological chemistry 2001 Nov 30;276(48):45175-83
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- GAB2 Antibody (N-term) (ABIN1881358) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- GAB2 Antibody (N-term) (ABIN1881358) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.