BS9120

antibody from Bioworld Technology, Inc
Targeting: GAB2 KIAA0571
Provider product page for BS9120
Western blot
Immunohistochemistry

Antibody data

Product number
BS9120 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Gab 2 (L617) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 587-634 of Human Gab 2.
Description
Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major Insulin receptor substrate. Shc and Gab 1 also participate in Insulin signaling by linking the Insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. The Gap 1 related protein, Gab 2, associates with SH2 domain-containing proteins, such as SHP2, and it is involved in a novel pathway for cytokine-induced gene activation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GAB2 protein structure - BS9120 shown in red.