BS6671

antibody from Bioworld Technology, Inc
Targeting: MSR1 CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII
Provider product page for BS6671
Western blot
Immunohistochemistry

Antibody data

Product number
BS6671 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MSR1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MSR1.
Description
The macrophage class A scavenger receptor (SR-A) mediates the uptake of modified low density lipoprotein (LDL). The gene encoding human SR-A maps to chromosome 8 and gives rise to two alternatively spliced isoforms, type I and II (SR-AI and SR-AII), which were originally cloned from the phorbol ester-treated human monocytic cell line THP-1. Both isoforms contain six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V) and a type-specific C-terminal (VI)). Domain IV is essential for the trimerization of SR-A, whereas domain V is essential for the wide range of ligand recognition. SR-A is expressed in liver, placenta and brain. Both SR-AI and SR-AII mediate the uptake of LDLs in atherosclerotic lesions. A third isoform,
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MSR1 protein structure - BS6671 shown in red.