BS5755

antibody from Bioworld Technology, Inc
Targeting: NDC80 HEC, HEC1, hsNDC80, KNTC2, TID3
Provider product page for BS5755
Western blot
Immunocytochemistry

Antibody data

Product number
BS5755 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HEC1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to the 388-433 of Human HEC1.
Description
Highly expressed in cancer (Hec1) is a coiled-coil-enriched protein expressed abundantly in the S and M phases of rapidly dividing cells where it localizes to the kinetochores. Hec1 is involved in spindle checkpoint signaling. Hec1 is not expressed in terminal differentiated cells. Hec1 is expressed in tissues with high mitotic rates including testis, spleen and thymus. Hec1 is also found in the late S to M phases of bladder carcinoma cells. In dividing cells, Hec1 is required for the recruitment of Mps1 kinase and MAD1/MAD2 complexes to the kinetochores. The phosphorylation of Hec1 on Serine 165 by Nek2 is essential for faithful chromosome segregation. The binding of retinoblastoma protein to Hec1 also increases the fidelity of chromosomal segregation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NDC80 protein structure - BS5755 shown in red.