abx012267

antibody from Abbexa

Targeting: TNK1 KOS1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

abx012267

Provider

Abbexa

Product name

Tyrosine Kinase Non Receptor 1 (TNK1) Antibody

Antibody type

Monoclonal

Description

TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase (NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.