Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- ELISA [1]
- Flow cytometry [1]
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Validation data
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- Product number
- MAB7144 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal B7-H6 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human B7-H6 in ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production.
B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines.
Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.
Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20.
Anft M, Netter P, Urlaub D, Prager I, Schaffner S, Watzl C
Cellular & molecular immunology 2020 Apr;17(4):347-355
Cellular & molecular immunology 2020 Apr;17(4):347-355
B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines.
Bjørnsen EG, Thiruchelvam-Kyle L, Hoelsbrekken SE, Henden C, Saether PC, Boysen P, Daws MR, Dissen E
European journal of immunology 2019 Jan;49(1):54-65
European journal of immunology 2019 Jan;49(1):54-65
Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.
Fielding CA, Weekes MP, Nobre LV, Ruckova E, Wilkie GS, Paulo JA, Chang C, Suárez NM, Davies JA, Antrobus R, Stanton RJ, Aicheler RJ, Nichols H, Vojtesek B, Trowsdale J, Davison AJ, Gygi SP, Tomasec P, Lehner PJ, Wilkinson GW
eLife 2017 Feb 10;6
eLife 2017 Feb 10;6
Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20.
Charpak-Amikam Y, Kubsch T, Seidel E, Oiknine-Djian E, Cavaletto N, Yamin R, Schmiedel D, Wolf D, Gribaudo G, Messerle M, Cicin-Sain L, Mandelboim O
Scientific reports 2017 Aug 17;7(1):8661
Scientific reports 2017 Aug 17;7(1):8661
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Human B7-H6 ELISA Standard Curve. Human B7-H6 ELISA Standard Curve.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of B7-H6 in HeLa Human Cell Line by Flow Cytometry. Detection of B7-H6 in HeLa Human Cell Line by Flow Cytometry.