Antibody data
- Antibody Data
- Antigen structure
- References [35]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 13300-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13300-1-AP, RRID:AB_10641988
- Product name
- TRIB3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIB3 antibody (Cat. #13300-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas.
TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis.
Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3.
TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.
A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway.
Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis.
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway.
Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints.
TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
p62/sequestosome 1 attenuates methylmercury-induced endoplasmic reticulum stress in mouse embryonic fibroblasts.
TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.
TRIB3 promotes hepatocellular carcinoma growth and predicts poor prognosis.
Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway.
Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage.
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints.
TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway.
TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance.
Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation.
Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma.
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.
Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer.
Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.
Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein.
Transcriptome analysis of genes regulated by cholesterol loading in two strains of mouse macrophages associates lysosome pathway and ER stress response with atherosclerosis susceptibility.
Zeng S, Wang Y, Ai L, Huang L, Liu Z, He C, Bai Q, Li Y
Clinical and experimental pharmacology & physiology 2024 Mar;51(3):e13843
Clinical and experimental pharmacology & physiology 2024 Mar;51(3):e13843
TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.
Chen L, Lin W, Zhang H, Geng S, Le Z, Wan F, Huang Q, Chen H, Liu X, Lu JJ, Kong L
Cell death & disease 2024 Mar 1;15(3):178
Cell death & disease 2024 Mar 1;15(3):178
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis.
Hattori T, Fundora KA, Hamamoto K, Opozda DM, Liang X, Liu X, Zhang J, Uzun Y, Takahashi Y, Wang HG
Autophagy 2024 Feb;20(2):349-364
Autophagy 2024 Feb;20(2):349-364
Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3.
Hu C, Li Q, Xiang L, Luo Y, Li S, An J, Yu X, Zhang G, Chen Y, Wang Y, Wang D
Computational and structural biotechnology journal 2024 Dec;23:234-250
Computational and structural biotechnology journal 2024 Dec;23:234-250
TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.
Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977
Archives of oral biology 2024 Aug;164:105977
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Dai Y, Xu R, Chen J, Fang J, Zhang H, Li H, Chen W
British journal of pharmacology 2024 Apr;181(7):967-986
British journal of pharmacology 2024 Apr;181(7):967-986
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.
Muley H, Dowdy T, Zaibaq F, Karadimov G, Li A, Song H, Zhang M, Zhang W, Wong Z, Zhang L, Lita A, Larion M
bioRxiv : the preprint server for biology 2024 Apr 29;
bioRxiv : the preprint server for biology 2024 Apr 29;
A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
Fu Q, Yi B, Su Q, Huang Y, Wang L, Zhang Z
Aging 2023 Nov 22;15(22):13213-13238
Aging 2023 Nov 22;15(22):13213-13238
Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway.
Zhang W, Liu M, Ji Y, Yu D, Ma C, Zhao J, Qu P
Archives of biochemistry and biophysics 2023 Jul 15;743:109655
Archives of biochemistry and biophysics 2023 Jul 15;743:109655
Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis.
Shi L, Li Y, Shi M, Li X, Li G, Cen J, Liu D, Wei C, Lin Y
Oxidative medicine and cellular longevity 2022;2022:5142381
Oxidative medicine and cellular longevity 2022;2022:5142381
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Márton M, Bánhegyi G, Gyöngyösi N, Kálmán EÉ, Pettkó-Szandtner A, Káldi K, Kapuy O
FEBS open bio 2022 Nov;12(11):2065-2082
FEBS open bio 2022 Nov;12(11):2065-2082
Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway.
He X, Wu D, Xu Y, Zhang Y, Sun Y, Chang X, Zhu Y, Tang W
Environmental science and pollution research international 2022 Dec;29(56):84532-84545
Environmental science and pollution research international 2022 Dec;29(56):84532-84545
Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints.
Tan L, Harper LR, Armstrong A, Carlson CS, Yammani RR
PloS one 2021;16(2):e0247237
PloS one 2021;16(2):e0247237
TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.
Wang N, Si C, Xia L, Wu X, Zhao S, Xu H, Ding Z, Niu Z
Reproductive biology and endocrinology : RB&E 2021 Sep 9;19(1):139
Reproductive biology and endocrinology : RB&E 2021 Sep 9;19(1):139
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
Zhao Y, Yang X, Li S, Zhang B, Li S, Wang X, Wang Y, Jia C, Chang Y, Wei W
Stem cell research & therapy 2021 Oct 9;12(1):535
Stem cell research & therapy 2021 Oct 9;12(1):535
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606
Autophagy 2021 Nov;17(11):3592-3606
p62/sequestosome 1 attenuates methylmercury-induced endoplasmic reticulum stress in mouse embryonic fibroblasts.
Takanezawa Y, Nakamura R, Sugimoto T, Ohshiro Y, Uraguchi S, Kiyono M
Toxicology letters 2021 Dec 15;353:93-99
Toxicology letters 2021 Dec 15;353:93-99
TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.
Cao X, Fang X, Guo M, Li X, He Y, Xie M, Xu Y, Liu X
Respiratory research 2021 Dec 14;22(1):312
Respiratory research 2021 Dec 14;22(1):312
TRIB3 promotes hepatocellular carcinoma growth and predicts poor prognosis.
Wang XJ, Li FF, Zhang YJ, Jiang M, Ren WH
Cancer biomarkers : section A of Disease markers 2020;29(3):307-315
Cancer biomarkers : section A of Disease markers 2020;29(3):307-315
Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway.
Wang S, Wang C, Li X, Hu Y, Gou R, Guo Q, Nie X, Liu J, Zhu L, Lin B
Cancer cell international 2020;20:418
Cancer cell international 2020;20:418
Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage.
Tan L, Register TC, Yammani RR
Aging and disease 2020 Oct;11(5):1091-1102
Aging and disease 2020 Oct;11(5):1091-1102
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Li B, Yao J, Guo K, He F, Chen K, Lin Z, Liu S, Huang J, Wu Q, Fang M, Zeng J, Wu Z
European journal of medicinal chemistry 2020 Oct 15;204:112608
European journal of medicinal chemistry 2020 Oct 15;204:112608
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Wang F, Liu L, Tong Y, Li L, Liu Y, Gao WQ
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.
Poncet N, Halley PA, Lipina C, Gierliński M, Dady A, Singer GA, Febrer M, Shi YB, Yamaguchi TP, Taylor PM, Storey KG
EMBO reports 2020 Jan 7;21(1):e48469
EMBO reports 2020 Jan 7;21(1):e48469
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints.
Tan L, Harper L, McNulty MA, Carlson CS, Yammani RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5818-5826
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5818-5826
TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway.
Qu J, Liu B, Li B, Du G, Li Y, Wang J, He L, Wan X
OncoTargets and therapy 2019;12:2235-2245
OncoTargets and therapy 2019;12:2235-2245
TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance.
Lin J, Zhang W, Niu LT, Zhu YM, Weng XQ, Sheng Y, Zhu J, Xu J
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Oct 15;25(20):6228-6242
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Oct 15;25(20):6228-6242
Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation.
Lee YC, Wang WL, Chang WC, Huang YH, Hong GC, Wang HL, Chou YH, Tseng HC, Lee HT, Li ST, Chen HL, Wu CC, Yang HF, Wang BY, Chang WW
Cancers 2019 Jan 22;11(2)
Cancers 2019 Jan 22;11(2)
Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma.
Buondonno I, Gazzano E, Tavanti E, Chegaev K, Kopecka J, Fanelli M, Rolando B, Fruttero R, Gasco A, Hattinger C, Serra M, Riganti C
Cellular and molecular life sciences : CMLS 2019 Feb;76(3):609-625
Cellular and molecular life sciences : CMLS 2019 Feb;76(3):609-625
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.
Gazzano E, Buondonno I, Marengo A, Rolando B, Chegaev K, Kopecka J, Saponara S, Sorge M, Hattinger CM, Gasco A, Fruttero R, Brancaccio M, Serra M, Stella B, Fattal E, Arpicco S, Riganti C
Cancer letters 2019 Aug 1;456:29-39
Cancer letters 2019 Aug 1;456:29-39
Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer.
Salaroglio IC, Gazzano E, Abdullrahman A, Mungo E, Castella B, Abd-Elrahman GEFA, Massaia M, Donadelli M, Rubinstein M, Riganti C, Kopecka J
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):286
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):286
Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.
Kopecka J, Salaroglio IC, Righi L, Libener R, Orecchia S, Grosso F, Milosevic V, Ananthanarayanan P, Ricci L, Capelletto E, Pradotto M, Napoli F, Di Maio M, Novello S, Rubinstein M, Scagliotti GV, Riganti C
Lung cancer (Amsterdam, Netherlands) 2018 Jun;120:34-45
Lung cancer (Amsterdam, Netherlands) 2018 Jun;120:34-45
Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein.
Riganti C, Gazzano E, Gulino GR, Volante M, Ghigo D, Kopecka J
Cancer letters 2015 May 1;360(2):219-26
Cancer letters 2015 May 1;360(2):219-26
Transcriptome analysis of genes regulated by cholesterol loading in two strains of mouse macrophages associates lysosome pathway and ER stress response with atherosclerosis susceptibility.
Berisha SZ, Hsu J, Robinet P, Smith JD
PloS one 2013;8(5):e65003
PloS one 2013;8(5):e65003
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIB3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIB3. This antibody recognizes human,mouse,rat antigen. The TRIB3 antibody has been validated for the following applications: ELISA, WB analysis.