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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Immunohistochemistry [1]
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- Product number
- 600-401-965S - Provider product page
- Provider
- Rockland Immunochemicals, Inc.
- Proper citation
- Rockland Cat#600-401-965S, RRID:AB_11180072
- Product name
- Anti-Pdcd4 (RABBIT) Antibody - 600-401-965S
- Antibody type
- Polyclonal
- Vial size
- 25 µl
Submitted references A high-throughput pipeline for validation of antibodies.
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
Systematic Functional Annotation of Somatic Mutations in Cancer.
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.
ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1.
The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo.
CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.
The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.
Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer.
Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, Nyman TA, Stensland ME, Zhou W, de Souza GA, Holden L, Stuchly J, Templin M, Lund-Johansen F
Nature methods 2018 Nov;15(11):909-912
Nature methods 2018 Nov;15(11):909-912
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ
Cell reports 2018 Nov 20;25(8):2148-2162.e5
Cell reports 2018 Nov 20;25(8):2148-2162.e5
Systematic Functional Annotation of Somatic Mutations in Cancer.
Ng PK, Li J, Jeong KJ, Shao S, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Gao J, Tokheim C, Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Schultz N, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB
Cancer cell 2018 Mar 12;33(3):450-462.e10
Cancer cell 2018 Mar 12;33(3):450-462.e10
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Hill SM, Nesser NK, Johnson-Camacho K, Jeffress M, Johnson A, Boniface C, Spencer SE, Lu Y, Heiser LM, Lawrence Y, Pande NT, Korkola JE, Gray JW, Mills GB, Mukherjee S, Spellman PT
Cell systems 2017 Jan 25;4(1):73-83.e10
Cell systems 2017 Jan 25;4(1):73-83.e10
Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.
Kudinov AE, Deneka A, Nikonova AS, Beck TN, Ahn YH, Liu X, Martinez CF, Schultz FA, Reynolds S, Yang DH, Cai KQ, Yaghmour KM, Baker KA, Egleston BL, Nicolas E, Chikwem A, Andrianov G, Singh S, Borghaei H, Serebriiskii IG, Gibbons DL, Kurie JM, Golemis EA, Boumber Y
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 21;113(25):6955-60
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 21;113(25):6955-60
ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
Liwak-Muir U, Dobson CC, Naing T, Wylie Q, Chehade L, Baird SD, Chakraborty PK, Holcik M
Oncotarget 2016 Jan 12;7(2):1439-50
Oncotarget 2016 Jan 12;7(2):1439-50
MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1.
Sharma SB, Lin CC, Farrugia MK, McLaughlin SL, Ellis EJ, Brundage KM, Salkeni MA, Ruppert JM
Molecular and cellular biology 2014 Nov 15;34(22):4143-64
Molecular and cellular biology 2014 Nov 15;34(22):4143-64
The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo.
Yang CH, Yue J, Sims M, Pfeffer LM
PloS one 2013;8(8):e71130
PloS one 2013;8(8):e71130
CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.
Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O, Asakura K, Saya H, Hibi T
British journal of cancer 2013 Jul 23;109(2):379-86
British journal of cancer 2013 Jul 23;109(2):379-86
The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.
Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson DS, Matschinsky F, Shi W, Chen YH
Proceedings of the National Academy of Sciences of the United States of America 2011 Jul 19;108(29):12030-5
Proceedings of the National Academy of Sciences of the United States of America 2011 Jul 19;108(29):12030-5
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.
Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA
Nature immunology 2010 Feb;11(2):141-7
Nature immunology 2010 Feb;11(2):141-7
Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer.
Wei NA, Liu SS, Leung TH, Tam KF, Liao XY, Cheung AN, Chan KK, Ngan HY
Molecular cancer 2009 Sep 3;8:70
Molecular cancer 2009 Sep 3;8:70
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Supportive validation
- Submitted by
- Rockland Immunochemicals, Inc. (provider)
- Main image
- Experimental details
- Affinity purified anti-Pdcd4 was used at a 1:100 dilution to detect Pdcd4 by immunohistochemistry on mouse colon tissue. Tissue was fixed in 4% paraformaldehyde and paraffin embedded. Tissue sections were deparaffinized and treated by trypsinization before staining. Personal Communication. M Young, NCI, Bethesda, MD.
- Validation comment
- Immunohistochemistry
