11-6007-25
antibody from ABEOMICS Inc.
Targeting: RBCK1
C20orf18, HOIL1, RBCK2, RNF54, UBCE7IP3, XAP4, ZRANB4
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-6007-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-HOIL-1L/RBCK1 Antibody
- Antibody type
- Polyclonal
- Description
- RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1) is a transcription factor belonging to the RING-IBR protein family. It shuttles between the nucleus and cytoplasm, possessing both the nuclear export and localization signals within its amino acid sequence. RBCK1 deficiency causes polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy. RBCK1 negatively regulates the cellular antiviral response. RBCK1 regulates cell cycle progression and proliferation of ERalpha (estrogen receptor alpha)-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant HOIL-1
L/RBCK1 protein (amino acids 121-33
3) was used as the immunogen for th
is antibody.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of HOIL-1L/RBCK. Anti-HOIL-1L/RBCK antibody (11-6007) was used at 2 µg/ml on (1) A375, (2) 293 and (3) Jurkat lysates.