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LearnNBP1-88301
antibody from Novus Biologicals
Targeting: RBCK1
C20orf18, HOIL1, RBCK2, RNF54, UBCE7IP3, XAP4, ZRANB4
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [2]
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- Product number
- NBP1-88301 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-88301, RRID:AB_11018853
- Product name
- Rabbit Polyclonal RBCK1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human RBCK1 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.
Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella.
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.
UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, Sawasaki T
Biochemical and biophysical research communications 2020 Mar 26;524(1):1-7
Biochemical and biophysical research communications 2020 Mar 26;524(1):1-7
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.
Douglas T, Saleh M
The Journal of biological chemistry 2020 Apr 17;295(16):5216-5228
The Journal of biological chemistry 2020 Apr 17;295(16):5216-5228
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.
MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW
Journal of virology 2018 Dec 1;92(23)
Journal of virology 2018 Dec 1;92(23)
Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella.
Polajnar M, Dietz MS, Heilemann M, Behrends C
EMBO reports 2017 Sep;18(9):1572-1585
EMBO reports 2017 Sep;18(9):1572-1585
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI
PLoS pathogens 2017 Jan;13(1):e1006162
PLoS pathogens 2017 Jan;13(1):e1006162
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F
Nature communications 2016 Aug 24;7:12547
Nature communications 2016 Aug 24;7:12547
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.
Klein T, Fung SY, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE, Overall CM
Nature communications 2015 Nov 3;6:8777
Nature communications 2015 Nov 3;6:8777
UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H, Vyse TJ
American journal of human genetics 2015 Feb 5;96(2):221-34
American journal of human genetics 2015 Feb 5;96(2):221-34
Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O
PloS one 2013;8(10):e76983
PloS one 2013;8(10):e76983
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M
Molecular cell 2013 Jun 27;50(6):818-830
Molecular cell 2013 Jun 27;50(6):818-830
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: RBCK1 Antibody [NBP1-88301] - Analysis in human cell line HepG2.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: RBCK1 Antibody [NBP1-88301] - Analysis in human cell lines SK-MEL-30 and HeLa using anti-RBCK1 antibody. Corresponding RBCK1 RNA-seq data are presented for the same cell lines. Loading control: anti-PFN1.
