DLG5

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Description

Discs large MAGUK scaffold protein 5

Tissue specificity

Low tissue specificity

Subcell location

Cell Junctions

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (77790791 - 77926755)

Ensembl ID

ENSG00000151208  (ver. 103.38)

Orthologs

Mouse Dlg5: ENSMUSG00000021782

UniProt

Q8TDM6

neXtProt

NX_Q8TDM6

Human splice variants
Mouse splice variants

Protein structure