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- References [13]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 22989-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MMP12 antibody
- Antibody type
- Polyclonal
- Description
- MMP12 antibody (Cat. #22989-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis.
MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.
Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice.
Splenectomy enhances the Ly6Clow phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via EGFR.
Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.
Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling.
Role of PM2.5 in the development and progression of COPD and its mechanisms.
Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer.
The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases.
Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways.
Nighot M, Ganapathy AS, Saha K, Suchanec E, Castillo EF, Gregory A, Shapiro S, Ma T, Nighot P
Journal of Crohn's & colitis 2021 Oct 7;15(10):1751-1765
Journal of Crohn's & colitis 2021 Oct 7;15(10):1751-1765
MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.
Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C, Chen S
Biomaterials 2021 Nov;278:121183
Biomaterials 2021 Nov;278:121183
Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice.
Yamashita-Futani Y, Jokaji R, Ooi K, Kobayashi K, Kanakis I, Liu K, Kawashiri S, Bou-Gharios G, Nakamura H
Biomedical reports 2021 Jun;14(6):51
Biomedical reports 2021 Jun;14(6):51
Splenectomy enhances the Ly6Clow phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Zheng Z, Wang H, Li L, Zhang S, Zhang C, Zhang H, Ji F, Liu X, Zhu K, Kong G, Li Z
International immunopharmacology 2020 Sep;86:106762
International immunopharmacology 2020 Sep;86:106762
Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via EGFR.
Chen ZH, Luo XC, Yu CR, Huang L
Molecular and cellular neurosciences 2020 Oct;108:103552
Molecular and cellular neurosciences 2020 Oct;108:103552
Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Wu BM, Liu JD, Li YH, Li J
International journal of molecular medicine 2020 Jan;45(1):103-114
International journal of molecular medicine 2020 Jan;45(1):103-114
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, Xu J, Li D, Yao H, Liu W, Deng B, Lu W
Redox biology 2020 Jan;28:101356
Redox biology 2020 Jan;28:101356
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.
Boytard L, Hadi T, Silvestro M, Qu H, Kumpfbeck A, Sleiman R, Fils KH, Alebrahim D, Boccalatte F, Kugler M, Corsica A, Gelb BE, Jacobowitz G, Miller G, Bellini C, Oakes J, Silvestre JS, Zangi L, Ramkhelawon B
Nature communications 2020 Aug 27;11(1):4311
Nature communications 2020 Aug 27;11(1):4311
Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling.
Zhang XF, Ding MJ, Cheng C, Zhang Y, Xiang SY, Lu J, Liu ZB
International immunopharmacology 2020 Apr;81:106230
International immunopharmacology 2020 Apr;81:106230
Role of PM2.5 in the development and progression of COPD and its mechanisms.
Zhao J, Li M, Wang Z, Chen J, Zhao J, Xu Y, Wei X, Wang J, Xie J
Respiratory research 2019 Jun 13;20(1):120
Respiratory research 2019 Jun 13;20(1):120
Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer.
Jin H, Liu P, Wu Y, Meng X, Wu M, Han J, Tan X
Cancer science 2018 Sep;109(9):2946-2956
Cancer science 2018 Sep;109(9):2946-2956
The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases.
Rizzo P, Novelli R, Rota C, Gagliardini E, Ruggiero B, Rottoli D, Benigni A, Remuzzi G
The American journal of pathology 2017 Nov;187(11):2441-2450
The American journal of pathology 2017 Nov;187(11):2441-2450
Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways.
Xiao X, He Z, Cao W, Cai F, Zhang L, Huang Q, Fan C, Duan C, Wang X, Wang J, Liu Y
International journal of oncology 2016 Jun;48(6):2608-18
International journal of oncology 2016 Jun;48(6):2608-18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 22989-1-AP( MMP12 Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MMP12 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MMP12. This antibody recognizes human, mouse antigen. The MMP12 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
