10-3018

antibody from ABEOMICS Inc.

Targeting: NLRP3 AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1

Antibody data

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Validation data

Product number: 10-3018 - Provider product page
Provider: ABEOMICS Inc.
Product name: Anti-NALP3 Antibody
Antibody type: Monoclonal
Description: NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: A partial length recombinant NALP3 protein (amino acids 150-385) was u sed as the immunogen for this antib ody.
Isotype: IgG
Antibody clone number: ABM2D48
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing

NLRP3 protein structure - 10-3018 shown in red.